Noninvasive Fetal Electrocardiography Part II: Segmented-Beat Modulation Method for Signal Denoising.

BACKGROUND

Fetal well-being evaluation may be accomplished by monitoring cardiac activity through fetal electrocardiography. Direct fetal electrocardiography (acquired through scalp electrodes) is the gold standard but its invasiveness limits its clinical applicability. Instead, clinical use of indirect fetal electrocardiography (acquired through abdominal electrodes) is limited by its poor signal quality.

OBJECTIVE

Aim of this study was to evaluate the suitability of the Segmented-Beat Modulation Method to denoise indirect fetal electrocardiograms in order to achieve a signal-quality at least comparable to the direct ones.

METHOD

Direct and indirect recordings, simultaneously acquired from 5 pregnant women during labor, were filtered with the Segmented-Beat Modulation Method and correlated in order to assess their morphological correspondence. Signal-to-noise ratio was used to quantify their quality.

RESULTS

Amplitude was higher in direct than indirect fetal electrocardiograms (median:104 µV 22 µV; P=7.66·10), whereas noise was comparable (median:70 µV 49 µV, P=0.45). Moreover, fetal electrocardiogram amplitude was significantly higher than affecting noise in direct recording (P=3.17·10) and significantly in indirect recording (P=1.90·10). Consequently, signal-to-noise ratio was initially higher for direct than indirect recordings (median:3.3 dB -2.3 dB; P=3.90·10), but became lower after denoising of indirect ones (median:9.6 dB; P=9.84·10). Eventually, direct and indirect recordings were highly correlated (median: ρ=0.78; P<10), indicating that the two electrocardiograms were morphologically equivalent.

CONCLUSION

Segmented-Beat Modulation Method is particularly useful for denoising of indirect fetal electrocardiogram and may contribute to the spread of this noninvasive technique in the clinical practice.