Pickering T G, Sos T A, James G D, Vaughan E D, Sealey J E, Laragh J H
Cardiovascular Center, New York Hospital/Cornell University Medical College, New York 10021.
J Hypertens Suppl. 1985 Dec;3(3):S291-3.
Renal vein renin measurements were compared in 64 hypertensive patients with arteriographically documented stenoses or complete occlusion of one or both renal arteries. The characteristic pattern of curable renovascular hypertension, i.e. increased increment of renin from the ischaemic kidney with contralateral suppression of renin secretion, was seen not only in patients with unilateral stenoses, but also in most patients with bilateral stenoses. Contralateral suppression was less marked in azotemic patients. The highest increments of renal vein renin were seen when the renal artery was completely occluded. The patterns were similar following acute or chronic administration of captopril, suggesting that angiotensin II is not responsible. Increased sodium delivery to the macula densa is postulated as a possible cause of contralateral suppression.
对64例经血管造影证实有一侧或双侧肾动脉狭窄或完全闭塞的高血压患者进行了肾静脉肾素测定。可治愈的肾血管性高血压的特征性模式，即缺血肾的肾素增量增加，对侧肾素分泌受抑制，不仅见于单侧狭窄患者，也见于大多数双侧狭窄患者。氮质血症患者的对侧抑制不太明显。当肾动脉完全闭塞时，肾静脉肾素的增量最高。急性或慢性服用卡托普利后的模式相似，提示血管紧张素II与此无关。推测致密斑钠输送增加可能是对侧抑制的原因。
