Holstein-Rathlou N H, Leyssac P P
University Institute for Experimental Medicine, Copenhagen, Denmark.
J Hypertens Suppl. 1985 Dec;3(3):S343-5.
In 12 to 18-week-old Wistar-Kyoto rats, regular oscillations in the proximal intratubular pressure occurred spontaneously. The median frequency was 29.7 mHz (range 20-46.7 mHz). In spontaneously hypertensive rats, spontaneous oscillations also occurred, but these were highly irregular. In both strains, oscillations could be elicited by free flow microperfusion with artificial tubular fluid. When furosemide was added to the artificial tubular fluid in a concentration of 0.1 mmol/l, the oscillations were abolished in both strains of rats. It is concluded that, in both strains of rats, the oscillatory phenomena depend upon tubuloglomerular feedback activity, and that the differences in the oscillatory patterns between the two strain of rats represent a difference in the parameter setting of the tubuloglomerular feedback system.
在12至18周龄的Wistar-Kyoto大鼠中，近端肾小管内压力会自发出现规律性振荡。中位频率为29.7毫赫兹（范围为20 - 46.7毫赫兹）。在自发性高血压大鼠中，也会出现自发振荡，但这些振荡非常不规则。在这两种品系的大鼠中，通过用人工肾小管液进行自由流动微灌注均可引发振荡。当在人工肾小管液中加入浓度为0.1毫摩尔/升的呋塞米时，两种品系的大鼠的振荡均被消除。得出的结论是，在两种品系的大鼠中，振荡现象均依赖于肾小管-肾小球反馈活动，并且两种品系大鼠振荡模式的差异代表了肾小管-肾小球反馈系统参数设置的差异。
