Gastrointestinal Unit, Department of Gastroenterology, University of Pisa, Via Paradisa no. 2, 56100, Pisa, Italy.
Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Tech Coloproctol. 2017 Jun;21(6):451-459. doi: 10.1007/s10151-017-1639-3. Epub 2017 May 31.
The aim of this study was to determine the effects of a low fermentable oligo-, di- and monosaccharides and polyols (FODMAP) diet on the nutritional status and body composition, abdominal symptoms, quality of life, anxiety/depression and sleep quality of patients with irritable bowel syndrome (IBS).
Consecutive patients were given a low FODMAP diet for 8 weeks. At baseline and after 8 weeks, blood tests were taken to evaluate nutritional status and a bioelectrical impedance analysis was performed to assess body composition. Anthropometric data, IBS Symptom Severity Score, results of a bowel habits questionnaire, Bristol Stool Chart classification, SF36, Hamilton Depression Anxiety Scale outcome and Pittsburgh Sleep Quality Index were also recorded. During the 8-week diet period, the patients were phoned periodically by the nutritionist to verify their compliance.
Twenty-six IBS patients with a mean age of 46.2 ± 13.8 years were studied. After 8 weeks, there were no abnormalities in anthropometric data, bioelectrical impedance parameters and blood tests. The patients' IBS Symptom Severity Score improved (305.2 ± 84.1 vs 156.3 ± 106.4; p < 0.0001), as did bowel habits, Bristol Stool Chart classification, quality of life and HADS anxiety score, whereas sleeping quality and depression were unchanged. The degree of relief from symptoms and satisfaction with the diet was high.
A low FODMAP diet improved IBS symptoms without effects on nutritional status and body composition.
本研究旨在确定低发酵寡糖、双糖和单糖及多元醇（FODMAP）饮食对肠易激综合征（IBS）患者营养状况和身体成分、腹部症状、生活质量、焦虑/抑郁和睡眠质量的影响。
连续的患者接受低 FODMAP 饮食 8 周。在基线和 8 周后，采集血液样本以评估营养状况，并进行生物电阻抗分析以评估身体成分。还记录了人体测量数据、IBS 症状严重程度评分、排便习惯问卷结果、布里斯托粪便图表分类、SF36、汉密尔顿焦虑抑郁量表结果和匹兹堡睡眠质量指数。在 8 周的饮食期间，营养师定期打电话给患者以验证其依从性。
研究了 26 名平均年龄为 46.2±13.8 岁的 IBS 患者。8 周后，人体测量数据、生物电阻抗参数和血液检查均无异常。患者的 IBS 症状严重程度评分改善（305.2±84.1 与 156.3±106.4；p<0.0001），排便习惯、布里斯托粪便图表分类、生活质量和 HADS 焦虑评分也有所改善，而睡眠质量和抑郁则无变化。症状缓解程度和对饮食的满意度均较高。
低 FODMAP 饮食可改善 IBS 症状，而对营养状况和身体成分无影响。
