Jones C R, Elliott H L, Deighton N, Howie C A, Reid J L
University Department of Materia Medica, Stobhill General Hospital, Glasgow, UK.
J Hypertens Suppl. 1985 Dec;3(3):S153-5.
Alpha 2-receptor number was measured on platelets from 19 healthy normotensive volunteers and 19 patients with essential hypertension, using [3H]-yohimbine binding. Platelet function was assessed using the primary aggregation response to adrenaline. The mean alpha 2-receptor number (Bmax fmol/10(8) platelets) in platelets from normotensive controls was 31 (188 sites/cell) and was significantly higher than in age- and sex-matched hypertensive subjects, for whom Bmax = 24 (144 sites/cell) (P < 0.01 by paired t-test). There was no change in the affinity for [3H]-yohimbine binding. Platelet aggregation responses to adrenaline did not differ between hypertensive and normotensive subjects. Blood pressure reduction with prazosin in eight hypertensive subjects did not alter receptor number either acutely or following 1 month of treatment. These findings may be interpreted as evidence for enhanced receptor coupling to functional responses of a significantly smaller receptor population in patients with essential hypertension.
采用[3H] -育亨宾结合法，对19名健康血压正常志愿者和19名原发性高血压患者的血小板进行α2受体数量测定。通过对肾上腺素的初级聚集反应评估血小板功能。血压正常对照组血小板的平均α2受体数量（Bmax，fmol/10(8)个血小板）为31（188个位点/细胞），显著高于年龄和性别匹配的高血压患者，后者的Bmax = 24（144个位点/细胞）（配对t检验，P < 0.01）。[3H] -育亨宾结合的亲和力无变化。高血压患者和血压正常受试者对肾上腺素的血小板聚集反应无差异。8名高血压患者使用哌唑嗪降压，无论是急性用药还是治疗1个月后，均未改变受体数量。这些发现可解释为原发性高血压患者中，受体与明显较少受体群体的功能反应之间的偶联增强。
