Asadi-Samani Majid, Bagheri Nader, Rafieian-Kopaei Mahmoud, Shirzad Hedayatollah
Students Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Phytother Res. 2017 Aug;31(8):1128-1139. doi: 10.1002/ptr.5837. Epub 2017 Jun 1.
Searching for new natural drugs that are capable of targeting Th1 and Th17 may lead to development of more effective treatments for inflammatory and autoimmune diseases. Most of the natural drugs can be derived from plants that are used in traditional medicine and folk medicine. The aim of this systematic review is to identify and introduce plants or plant derivatives that are effective on inflammatory diseases by inhibiting Th1 and Th17 responses. To achieve this purpose, the search terms herb, herbal medicine, herbal drug, medicinal plant, phytochemical, traditional Chinese medicine, Ayurvedic medicine, natural compound, inflammation, inflammatory diseases, Th1, Th17, T helper 1 or T helper 17 were used separately in Title/Keywords/Abstract in Web of Science and PubMed databases. In articles investigating the effect of the medicinal plants and their derivatives in inhibiting Th1 and Th17 cells, the effects of eight extracts of the medicinal plants, 21 plant-based compounds and some of their derivatives, and eight drugs derived from the medicinal plants' compounds in inhibiting Th1 and Th17 cells were reviewed. The results showed that medicinal plants and their derivates are able to suppress Th17 and Th1 T cell functions as well as cytokine secretion and differentiation. The results can be used to produce herbal drugs that suppress Th, especially Th17, responses. Copyright © 2017 John Wiley & Sons, Ltd.
寻找能够靶向Th1和Th17的新型天然药物，可能会带来针对炎症性疾病和自身免疫性疾病更有效的治疗方法。大多数天然药物可源自传统医学和民间医学中使用的植物。本系统综述的目的是识别并介绍通过抑制Th1和Th17反应对炎症性疾病有效的植物或植物衍生物。为实现这一目的，检索词“草药”“草药医学”“草药药物”“药用植物”“植物化学物质”“传统中药”“阿育吠陀医学”“天然化合物”“炎症”“炎症性疾病”“Th1”“Th17”“辅助性T细胞1”或“辅助性T细胞17”分别用于科学网和PubMed数据库的标题/关键词/摘要中。在研究药用植物及其衍生物对Th1和Th17细胞抑制作用的文章中，综述了8种药用植物提取物、21种植物基化合物及其一些衍生物，以及8种源自药用植物化合物的药物对Th1和Th17细胞的抑制作用。结果表明，药用植物及其衍生物能够抑制Th17和Th1 T细胞功能以及细胞因子分泌和分化。这些结果可用于生产抑制Th，尤其是Th17反应的草药药物。版权所有© 2017约翰威立父子有限公司。
