Asadi-Samani Majid, Rafieian-Kopaei Mahmoud, Lorigooini Zahra, Shirzad Hedayatollah
Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Biomedicine (Taipei). 2018 Jun;8(2):8. doi: 10.1051/bmdcn/2018080208. Epub 2018 May 28.
Prostate cancer has been known as one of the most common malignancy in the men and it is therefore very important to prevent and treat this cancer. In this study, the anticancer effects of 20 species of medicinal plants in Iran, especially those grown in Chaharmahal and Bakhtiari province, were investigated on prostate cancer cell lines to identify potential natural alternatives for the development of prostate cancer anticancer drugs.
The plants were gathered from Chaharmahal va Bakhtyari and their aerial parts extracted through maceration method using ethanol 70%. Anti-proliferative activity of extracts on PC-3, DU145 and HDF cell lines was evaluated by MTT assay 48 hours after treatment.
Euphorbia szovitsii Fisch. & C.A.Mey. and Achillea wilhelmsii had anti-proliferative activity more than other plants on PC-3. Also IC50s for Urtica dioica, Euphorbia szovitsii Fisch. & C.A.Mey. and Medicago sativa were lower amount among the examined plants on Du-145.
According to our result, Euphorbia szovitsii Fisch. & C.A.Mey., U. dioica and Medicago sativa with good anti-proliferative activity can serve as an effective source of natural products to develop new antiprostate cancer drugs.
前列腺癌一直被认为是男性中最常见的恶性肿瘤之一，因此预防和治疗这种癌症非常重要。在本研究中，对伊朗的20种药用植物，特别是那些生长在恰哈马哈勒-巴赫蒂亚里省的植物，对前列腺癌细胞系的抗癌作用进行了研究，以确定开发前列腺癌抗癌药物的潜在天然替代品。
从恰哈马哈勒-巴赫蒂亚里采集植物，其地上部分通过使用70%乙醇的浸渍法提取。处理48小时后，通过MTT法评估提取物对PC-3、DU145和HDF细胞系的抗增殖活性。
苏维大戟和多花蓍对PC-3的抗增殖活性高于其他植物。在对Du-145检测的植物中，荨麻、苏维大戟和紫花苜蓿的半数抑制浓度也较低。
根据我们的结果，具有良好抗增殖活性的苏维大戟、荨麻和紫花苜蓿可作为开发新型抗前列腺癌药物的有效天然产物来源。
