外源性生长抑素输注对清醒犬胃肠道血流及激素的影响。

Effect of exogenous somatostatin infusion on gastrointestinal blood flow and hormones in the conscious dog.

作者信息

Price B A, Jaffe B M, Zinner M J

出版信息

Gastroenterology. 1985 Jan;88(1 Pt 1):80-5. doi: 10.1016/s0016-5085(85)80136-0.

Abstract

The purpose of this study was to investigate the effects of intravenous somatostatin infusion on gastrointestinal blood flow and hormone release in conscious dogs. Gastric, duodenal, jejunal, and pancreatic blood flows, quantitated using radioactive microspheres, were significantly decreased during somatostatin infusion (200 and 500 ng/kg min), resulting in an overall 30% reduction in summed portal blood flow. Fasting blood levels of glucose fell an average of 10 mg/dl. Immunoreactive insulin, gastrin, glucagon, and pancreatic polypeptide were all profoundly suppressed by somatostatin infusion. Our studies provide one possible explanation for somatostatin's apparent effectiveness in the control of upper gastrointestinal hemorrhage.

摘要

本研究的目的是探讨静脉输注生长抑素对清醒犬胃肠道血流及激素释放的影响。使用放射性微球定量测定的胃、十二指肠、空肠和胰腺血流，在输注生长抑素（200和500 ng/kg·min）期间显著降低，导致门静脉总血流量总体减少30%。空腹血糖水平平均下降10 mg/dl。免疫反应性胰岛素、胃泌素、胰高血糖素和胰多肽均被生长抑素输注显著抑制。我们的研究为生长抑素在控制上消化道出血方面的明显有效性提供了一种可能的解释。