生长抑素及其类似物在癌症治疗中的应用。综述。
Somatostatin and analogues in the treatment of cancer. A review.
作者信息
Evers B M, Parekh D, Townsend C M, Thompson J C
机构信息
Department of Surgery, University of Texas Medical Branch, Galveston 77550.
出版信息
Ann Surg. 1991 Mar;213(3):190-8. doi: 10.1097/00000658-199103000-00002.
Somatostatin is a naturally occurring cyclic tetradecapeptide that inhibits release of growth hormone and all gastrointestinal hormones. The beneficial effect of somatostatin in the treatment of certain hypersecretory disorders of hormone excess in well recognized; however its clinical usefulness has been limited in the past by its extremely short plasma half-life. The development of long-acting somatostatin analogues has provided clinically useful agents for treatment of hormone-producing tumors. In addition to well-known inhibiting effects on hormone release and actions, recent studies using experimental tumor models have demonstrated an antiproliferative effect of somatostatin and its analogues on growth of a variety of neoplasms. The exact role of somatostatin analogues in cancer therapy has yet to be established; however studies suggest that these agents could provide a useful and relatively nontoxic adjuvant therapy in the treatment of certain tumors. In this review, the oncologic application of somatostatin and possible mechanism of action are examined and current clinical and experimental studies are summarized.
生长抑素是一种天然存在的环十四肽，它能抑制生长激素及所有胃肠激素的释放。生长抑素在治疗某些激素分泌过多的分泌亢进性疾病方面的有益作用已得到广泛认可；然而，其临床应用过去因血浆半衰期极短而受到限制。长效生长抑素类似物的研发为治疗激素分泌性肿瘤提供了临床上有用的药物。除了对激素释放和作用具有众所周知的抑制作用外，最近使用实验性肿瘤模型的研究表明，生长抑素及其类似物对多种肿瘤的生长具有抗增殖作用。生长抑素类似物在癌症治疗中的确切作用尚未确定；然而，研究表明，这些药物在治疗某些肿瘤时可提供一种有用且相对无毒的辅助治疗。在这篇综述中，我们研究了生长抑素的肿瘤学应用及其可能的作用机制，并总结了当前的临床和实验研究。
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