O'Shaughnessy D J, Long R G, Adrian T E, Christofides N D, Ghatei M A, Sarson D L, Bloom S R
Digestion. 1985;31(4):234-42. doi: 10.1159/000199205.
Ingestion of a 4,500-kcal mixed meal by healthy volunteers resulted in a significant rise of plasma somatostatin-14-like immunoreactivity (9 +/- 1 pmol l-1. Whether this peptide has a role as a humoral agent or not is still controversial and, until recently, most studies investigating its effects by exogenous administration have produced vastly supraphysiological circulating plasma levels. In order to reproduce the rise obtained following the large meal, synthetic somatostatin-14 was infused at a dose of 0.8 pmol kg-1 min-1 before and during a 530-kcal test breakfast. This resulted in a rise of 8 + 2 pmol l-1 in the peripheral circulation. This infusion produced a significant reduction in the postprandial release of insulin, gastric inhibitory polypeptide, pancreatic polypeptide and in the preprandial motilin levels. In contrast, blood glucose levels following the breakfast were elevated when compared to the control saline infusion. This suggests that somatostatin possesses true endocrine functions and is capable of profoundly altering the postprandial glucose and hormone response.
健康志愿者摄入一顿4500千卡的混合餐会导致血浆中生长抑素-14样免疫反应性显著升高（9±1皮摩尔/升）。这种肽是否作为一种体液因子发挥作用仍存在争议，直到最近，大多数通过外源性给药研究其作用的实验都产生了远远高于生理水平的循环血浆浓度。为了重现大餐后出现的升高情况，在摄入一顿530千卡的测试早餐前及用餐期间，以0.8皮摩尔/千克/分钟的剂量输注合成生长抑素-14。这导致外周循环中升高了8±2皮摩尔/升。这种输注显著降低了餐后胰岛素、胃抑肽、胰多肽的释放以及餐前胃动素水平。相比之下，与输注生理盐水的对照组相比，早餐后的血糖水平升高了。这表明生长抑素具有真正的内分泌功能，并且能够深刻改变餐后血糖和激素反应。
