金催化的非对映选择性多米诺去芳构化/本位环化/氮杂迈克尔反应序列：一种便捷合成多种稠合氮杂螺四环骨架的方法。
Gold-catalyzed diastereoselective domino dearomatization/ipso-cyclization/aza-Michael sequence: a facile access to diverse fused azaspiro tetracyclic scaffolds.
作者信息
He Yi, Li Zhenghua, Tian Guilong, Song Liangliang, Van Meervelt Luc, Van der Eycken Erik V
机构信息
Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001, Leuven, Belgium.
出版信息
Chem Commun (Camb). 2017 Jun 13;53(48):6413-6416. doi: 10.1039/c7cc03152a.
A facile and diversity-oriented access to complex tetracyclic benzo[e]pyrrolo[2,3-c]indole-2,4,7(5H)-triones through a post-Ugi gold(i)-catalyzed domino dearomatization/ipso-cyclization/aza-Michael sequence is elaborated. This process furnishes tetracyclic scaffolds in good yields from readily available precursors with unique diastereoselectivity.
通过乌吉反应后金（I）催化的多米诺去芳构化/本位环化/氮杂迈克尔序列，实现了一种简便且具有多样性导向的方法来合成复杂的四环苯并[e]吡咯并[2,3-c]吲哚-2,4,7（5H）-三酮。该过程以容易获得的前体为原料，以良好的产率和独特的非对映选择性提供四环骨架。
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