Levine J H, Michael J R, Guarnieri T
Lancet. 1985 Jan 5;1(8419):12-4. doi: 10.1016/s0140-6736(85)90964-x.
Sixteen patients with multifocal atrial tachycardia (MAT) who were taking theophylline were identified over 6 months. After theophylline was discontinued the atrial rate fell and MAT resolved in all sixteen patients. Five patients were challenged with intravenous aminophylline to investigate the role of theophylline in the genesis of MAT. MAT with a rapid ventricular response occurred in all five even though metabolic and respiratory variables did not change. MAT returned on challenge in three patients in whom serum theophylline levels were within the generally accepted therapeutic range (10-20 mg/l). In individual patients, theophylline had a dose-related effect on the atrial rate and the amount of ectopic atrial activity. Thus, theophylline may commonly precipitate MAT and treatment with the drug should be carefully considered in patients with respiratory insufficiency and MAT.
在6个月的时间里，共识别出16名正在服用茶碱的多灶性房性心动过速（MAT）患者。停用茶碱后，所有16名患者的心房率下降，MAT消失。对5名患者进行了静脉注射氨茶碱的激发试验，以研究茶碱在MAT发生中的作用。尽管代谢和呼吸变量没有变化，但所有5名患者均出现了伴有快速心室反应的MAT。3名血清茶碱水平在公认治疗范围内（10 - 20 mg/l）的患者在激发试验时MAT复发。在个体患者中，茶碱对心房率和房性异位活动量有剂量相关效应。因此，茶碱可能常诱发MAT，对于呼吸功能不全合并MAT的患者，应谨慎考虑使用该药物进行治疗。
