幽门螺杆菌感染与胃十二指肠疾病患者血清胃蛋白酶原浓度之间的关联
Association between Helicobacter pylori infection and serum pepsinogen concentrations in gastroduodenal disease.
作者信息
Matsumoto K, Konishi N, Ohshima M, Hiasa Y, Kimura E, Samori T
机构信息
Development Section, Japan Clinical Laboratories, Inc., Osaka, Japan.
出版信息
J Clin Pathol. 1996 Dec;49(12):1005-8. doi: 10.1136/jcp.49.12.1005.
AIM
To investigate the association between Helicobacter pylori infection and serum pepsinogen (PG) 1 and 2 concentrations in various gastroduodenal diseases.
METHODS
Serum PG1 and 2 concentrations and antibodies to H pylori were measured by enzyme linked immunosorbent assay (ELISA); gastric mucosal pH was assessed and urease activity in biopsy tissue was determined. A comparison of the ELISA and urease test results permitted division of the cases into positive, false positive, false negative and negative categories for control, gastritis, and ulcer groups.
RESULTS
The gastric mucosal pH and serum PG2 in cases positive for H pylori were significantly increased in ulcer and gastritis cases compared with H pylori negative cases. Similar tendencies were observed for the false positive and false negative categories.
CONCLUSIONS
A positive ELISA reaction for antibodies and an increased serum PG2 concentration are reliable indicators of H pylori infection.
目的
探讨幽门螺杆菌感染与各种胃十二指肠疾病患者血清胃蛋白酶原（PG）1和2浓度之间的关联。
方法
采用酶联免疫吸附测定法（ELISA）检测血清PG1和2浓度以及幽门螺杆菌抗体；评估胃黏膜pH值并测定活检组织中的尿素酶活性。通过比较ELISA和尿素酶试验结果，将病例分为幽门螺杆菌阳性、假阳性、假阴性和阴性类别，用于对照、胃炎和溃疡组。
结果
与幽门螺杆菌阴性病例相比，溃疡和胃炎病例中幽门螺杆菌阳性患者的胃黏膜pH值和血清PG2显著升高。假阳性和假阴性类别也观察到类似趋势。
结论
ELISA抗体反应阳性和血清PG2浓度升高是幽门螺杆菌感染的可靠指标。
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