Jia Kai, Wang Rong, Tian Jingfeng
a Department of Nutrition , Beijing Chao-Yang Hospital, Capital Medical University , Beijing , China.
Nutr Cancer. 2017 Jul;69(5):723-731. doi: 10.1080/01635581.2017.1324633. Epub 2017 Jun 1.
We performed this meta-analysis to estimate the association between vitamin B intake and colorectal cancer risk.
Prospective cohort studies on vitamin B intake and colorectal cancer risk were identified by searching databases from the period of 1960 to 2016. Results from individual studies were synthetically combined using Stata 13.0 software.
A total of 10 prospective cohort studies including 13 data sets were included in our meta-analysis, containing 7,817 cases and 784,550 subjects. The combined relative risks (RR) of colorectal cancer for the highest vitamin B intake compared with the lowest vitamin B intake was 0.88 [95% confidence intervals (CIs): 0.77-1.02]. Dose-response meta-analysis based on five eligible studies showed that for each additional 3 and 5 mg of vitamin B intake, the risk would decrease by 11% (RR: 0.89, 95%CI: 0.81-0.98) and 17% (RR: 0.83, 95%CI: 0.71-0.97), respectively. Little evidence of publication bias was found.
This meta-analysis provides evidence of a nonsignificant decrease in colorectal cancer risk associated with the high level of vitamin B intake, but the risk in dose-response analysis is significant. However, the latter finding is based on a limited number of studies, which should be interpreted with caution.
我们进行了这项荟萃分析，以评估维生素B摄入量与结直肠癌风险之间的关联。
通过检索1960年至2016年期间的数据库，确定了关于维生素B摄入量与结直肠癌风险的前瞻性队列研究。使用Stata 13.0软件综合合并个体研究的结果。
我们的荟萃分析共纳入10项前瞻性队列研究，包括13个数据集，其中有7817例病例和784550名受试者。与最低维生素B摄入量相比，最高维生素B摄入量时结直肠癌的合并相对风险（RR）为0.88[95%置信区间（CI）：0.77 - 1.02]。基于五项符合条件的研究进行的剂量反应荟萃分析表明，维生素B摄入量每增加3毫克和5毫克，风险分别降低11%（RR：0.89，95%CI：0.81 - 0.98）和17%（RR：0.83，95%CI：0.71 - 0.97）。几乎没有发现发表偏倚的证据。
这项荟萃分析提供了证据，表明高维生素B摄入量与结直肠癌风险的降低无显著关联，但剂量反应分析中的风险具有显著性。然而，后一发现基于数量有限的研究，应谨慎解读。
