Food (Salt) Safety Research Center, Semnan University of Medical Sciences , Semnan , Iran.
Nursing Care Research Center, Semnan University of Medical Sciences , Semnan , Iran.
Crit Rev Food Sci Nutr. 2019;59(16):2697-2707. doi: 10.1080/10408398.2018.1511967. Epub 2018 Nov 15.
The objective of this study was to quantify the association of B-vitamins intake with the future risk of coronary heart disease (CHD). A systematic search was performed with the use of PubMed and Scopus from inception to April 30, 2018. Prospective cohort studies evaluating the association of intake of folate, vitamin B6, and vitamin B12 with risk of CHD in the general population were included. A random-effects meta-analysis was performed. Eleven prospective cohort studies (total = 369,746) with 5133 cases of CHD were included in the analyses. The relative risks were: 0.79 (95%CI: 0.69, 0.89; = 67%) for a 250 µg/d increment in folate intake; 0.87 (95%CI: 0.78, 0.96; = 80%) for a 0.5 mg/d increment in vitamin B6 intake; and 0.97 (95%CI: 0.80, 1.14: = 67%) for a 3 µg/d increment in vitamin B12 intake. The results did not change materially when the analyses were restricted only to dietary vitamins intake. A nonlinear dose-response meta-analysis demonstrated a linear inverse association between folate and vitamin B6 intake and risk of CHD. In conclusion, higher intake of folate and vitamin B6 is associated with a lower risk of CHD in the general population.
本研究旨在定量评估 B 族维生素摄入与未来冠心病（CHD）风险的相关性。使用 PubMed 和 Scopus 从建库至 2018 年 4 月 30 日进行了系统性检索。纳入了评估一般人群叶酸、维生素 B6 和维生素 B12 摄入量与 CHD 风险相关性的前瞻性队列研究。进行了随机效应荟萃分析。纳入了 11 项前瞻性队列研究（共 369746 人，发生 5133 例 CHD）。相对风险分别为：叶酸摄入量增加 250μg/d，相对风险为 0.79（95%CI：0.69，0.89； = 67%）；维生素 B6 摄入量增加 0.5mg/d，相对风险为 0.87（95%CI：0.78，0.96； = 80%）；维生素 B12 摄入量增加 3μg/d，相对风险为 0.97（95%CI：0.80，1.14： = 67%）。当仅分析膳食维生素摄入量时，分析结果无实质性变化。非线性剂量-反应荟萃分析表明，叶酸和维生素 B6 的摄入量与 CHD 的风险呈线性反比关系。总之，一般人群中叶酸和维生素 B6 的摄入量较高与 CHD 风险降低相关。
