Zhou Wangting, Chen Zhongjiang, Yang Sihua, Xing Da
Opt Lett. 2017 Jun 1;42(11):2145-2148. doi: 10.1364/OL.42.002145.
Basal cell carcinoma (BCC) and melanoma (MM), with the highest morbidity and mortality, respectively, are considered as two skin cancers of concern in dermatology. Histological studies have demonstrated that vascular patterns and collagenous stroma serve as key parameters for BCC and MM classification. In this Letter, we sought to identify BCC and MM based on the dual parameters of vascular patterns and scattering structures provided by all-optically integrated photoacoustic and optical coherence tomography (AOPA/OCT). The imaging capability of the AOPA/OCT was verified by the mimic phantoms. Furthermore, in vivo characterization of vasculatures and tissue structures from BCC and MM mice were successfully achieved with high resolution. Results prove the feasibility of AOPA/OCT as a novel method to dedicate to the in vivo biopsy of skin cancers which shows new insights into the study of skin diseases in early stages.
基底细胞癌（BCC）和黑色素瘤（MM）分别具有最高的发病率和死亡率，被认为是皮肤科关注的两种皮肤癌。组织学研究表明，血管模式和胶原基质是BCC和MM分类的关键参数。在这封信中，我们试图基于全光学集成光声和光学相干断层扫描（AOPA/OCT）提供的血管模式和散射结构的双重参数来识别BCC和MM。通过模拟体模验证了AOPA/OCT的成像能力。此外，成功地以高分辨率对BCC和MM小鼠的血管和组织结构进行了体内表征。结果证明了AOPA/OCT作为一种致力于皮肤癌体内活检的新方法的可行性，这为早期皮肤疾病的研究提供了新的见解。
