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腹腔镜尝试治疗的直肠癌病例转为开腹手术会影响短期和长期预后吗?一项系统评价和Meta分析。

Does Conversion to Open of Laparoscopically Attempted Rectal Cancer Cases Affect Short- and Long-Term Outcomes? A Systematic Review and Meta-Analysis.

作者信息

Gouvas Nikolaos, Georgiou Panagiotis A, Agalianos Christos, Tzovaras Georgios, Tekkis Paris, Xynos Evaghelos

机构信息

1 Department of Colorectal Surgery, Worcestershire Acute Hospitals NHS Trust , Worcester, United Kingdom .

2 Department of Surgery and Cancer, Imperial College , Chelsea and Westminster Campus, London, United Kingdom .

出版信息

J Laparoendosc Adv Surg Tech A. 2018 Feb;28(2):117-126. doi: 10.1089/lap.2017.0112. Epub 2017 Jun 1.

Abstract

INTRODUCTION

Laparoscopy for rectal cancer is a challenge as it presents many technical difficulties and requires high level of expertise. That is the reason for the high conversion rate. Reports on outcomes of converted cases after laparoscopic rectal resection for cancer are conflicting.

AIM

The present meta-analysis compares short- and long-term outcomes between converted rectal cancer cases with both open and laparoscopically completed cases.

METHOD

All studies reporting on outcomes separately for the converted cases were reviewed systematically. Main outcomes were intraoperative complications, procedure duration, short-term mortality and morbidity, length of stay, local recurrence, number of lymph nodes retrieved, and distant metastases. Quality assessment and data extraction were performed independently by 3 reviewers.

RESULTS

Fourteen studies were eligible for analysis, including 10,845 patients. Overall conversion rate was 11.9%. Converted cases had significantly longer duration, hospital stay, and higher rates of wound infection compared with laparoscopic cases. All other outcomes had no difference. When compared with open cases, conversions displayed longer operative times, but there was no other significant difference in the short- or long-term outcomes.

CONCLUSION

Converted cases seem to have some short-term unfavorable outcomes. Further retrospective analysis of big registries will be helpful for further investigation of converted cases.

摘要

引言

直肠癌的腹腔镜手术是一项挑战,因为它存在许多技术难题,需要高水平的专业技能。这就是其高中转率的原因。关于腹腔镜直肠癌切除术后中转病例的结局报告相互矛盾。

目的

本荟萃分析比较了直肠癌中转病例与开放手术完成病例及腹腔镜完成病例的短期和长期结局。

方法

系统回顾了所有分别报告中转病例结局的研究。主要结局包括术中并发症、手术时长、短期死亡率和发病率、住院时间、局部复发、获取的淋巴结数量及远处转移。由3名评审员独立进行质量评估和数据提取。

结果

14项研究符合分析条件,包括10845例患者。总体中转率为11.9%。与腹腔镜手术病例相比,中转病例的手术时长、住院时间显著更长,伤口感染率更高。所有其他结局无差异。与开放手术病例相比,中转病例的手术时间更长,但短期或长期结局无其他显著差异。

结论

中转病例似乎有一些短期不良结局。对大型登记数据库进行进一步的回顾性分析将有助于对中转病例进行进一步研究。

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