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腹腔镜与中转直肠癌切除术的早期临床及长期肿瘤学结局比较:一项回顾性队列研究

Comparison of Early Clinical and Long-Term Oncological Outcomes of Laparoscopic Versus Converted Rectal Cancer Resection: A Retrospective Cohort Study.

作者信息

Aday Ulas, Akbaş Abdulkadir, Bayrak Ferdi, Şekho Zehra, Közgün Azat, Sevmis Murat, Oğuz Abdullah

机构信息

Gastrointestinal Surgery, Dicle University, Diyarbakir, TUR.

General Surgery, Dicle University School of Medicine, Diyarbakır, TUR.

出版信息

Cureus. 2024 Jul 22;16(7):e65086. doi: 10.7759/cureus.65086. eCollection 2024 Jul.

Abstract

Aim The effects of conversion to open surgery during laparoscopic resection in rectal cancer on perioperative clinical and long-term oncological outcomes are still controversial. This study aimed to evaluate and compare the impact of conversion to laparoscopic resection for rectal cancer on perioperative and long-term oncological outcomes. Material and methods Between January 2019 and December 2023, 84 consecutive patients who underwent curative surgery for rectal cancer at a single academic center were evaluated retrospectively. Patients were classified and compared as the laparoscopic (LAP-G) and converted (CONV-G) groups. Perioperative, pathological, and long-term oncological outcomes were compared. Results Of the 84 consecutive patients included, 18 were converted to open surgery, leading to a 21.4% conversion rate. Intraoperative blood loss was higher in CONV-G (180 ml vs. 80 ml, p<0.001), but early clinical outcomes were similar in both groups. The median follow-up period was 23.5 (range 3-65) and 30.5 (range 6-61) months in the LAP-G and CONV-G, respectively, and recurrence occurred in 11 (16.7%) and 3 (16.6%) patients, respectively. Three-year overall survival was 96.9% and 89.4% (p=0.609) and 3-year disease-free survival was 92.4% and 83.3% (p=0.881) in LAP-G and CONV-G, respectively, and the results were similar. Conclusion Conversion from laparoscopic rectal resection to open surgery does not have a significant negative impact on morbidity and long-term oncological outcomes.

摘要

目的 直肠癌腹腔镜切除术中转为开放手术对围手术期临床及长期肿瘤学结局的影响仍存在争议。本研究旨在评估并比较直肠癌腹腔镜切除术中转为开放手术对围手术期及长期肿瘤学结局的影响。

材料与方法 回顾性评估2019年1月至2023年12月期间在单一学术中心接受直肠癌根治性手术的84例连续患者。将患者分为腹腔镜组(LAP-G)和中转组(CONV-G)并进行比较。比较围手术期、病理及长期肿瘤学结局。

结果 在纳入的84例连续患者中,18例转为开放手术,中转率为21.4%。CONV-G组术中失血量更高(180 ml对80 ml,p<0.001),但两组早期临床结局相似。LAP-G组和CONV-G组的中位随访期分别为23.5(范围3 - 65)个月和30.5(范围6 - 61)个月,复发患者分别为11例(16.7%)和3例(16.6%)。LAP-G组和CONV-G组的3年总生存率分别为96.9%和89.4%(p = 0.609),3年无病生存率分别为92.4%和83.3%(p = 0.881),结果相似。

结论 直肠癌腹腔镜切除转为开放手术对发病率及长期肿瘤学结局无显著负面影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7674/11338673/ed81d0f13555/cureus-0016-00000065086-i01.jpg

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