Radanovic Marcia, Mansur Leticia Lessa
Department of Neurology, Faculty of Medicine, University of Sao Paulo, Rua Dr. Eneas de Carvalho Aguiar, 225, 5th Floor, Sao Paulo, SP 05403-010, Brazil.
Department of Physiotherapy, Speech Therapy, and Occupational Therapy, Faculty of Medicine, University of Sao Paulo, Rua Cipotânea, 51, Cidade Universitaria, Sao Paulo, SP 05360-160, Brazil.
Brain Lang. 2017 Oct;173:20-32. doi: 10.1016/j.bandl.2017.05.003. Epub 2017 May 29.
Between 1970 and 1990, the study of aphasia secondary to subcortical lesions (including the basal ganglia - BG) was largely driven by the advent of modern neuroimaging techniques such as MRI and PET. However, attempts to characterize a pattern of language abnormalities in patients with basal ganglia lesions proved unfruitful. We conducted a comprehensive review of language disturbances after vascular lesions in the BG. Literature search in Medline and LILACS (1966-2016) and PsychINFO (last 25years) was conducted, and returned 145 articles, with 57 eligible for the review yielding data on 303 patients. We report the clinical and neuroimaging features of these cases. Results showed that aphasias caused by BG lesions are heterogeneous with weak clinicoanatomical correlations. Data derived from follow-up and flow/metabolism studies suggest that subcortical aphasia caused by BG lesions involves hypoperfusion in the cortical territories of the middle cerebral/internal carotid arteries (MCA/ICA) and their branches.
1970年至1990年间，对皮质下病变（包括基底神经节 - BG）继发的失语症的研究很大程度上受到MRI和PET等现代神经成像技术出现的推动。然而，试图描述基底神经节病变患者语言异常模式的尝试被证明是没有成效的。我们对BG血管病变后的语言障碍进行了全面综述。在Medline和LILACS（1966 - 2016年）以及PsychINFO（过去25年）中进行了文献检索，共检索到145篇文章，其中57篇符合综述要求，提供了303例患者的数据。我们报告了这些病例的临床和神经影像学特征。结果显示，BG病变引起的失语症具有异质性，临床解剖学相关性较弱。随访以及血流/代谢研究得出的数据表明，BG病变引起的皮质下失语症涉及大脑中动脉/颈内动脉（MCA/ICA）及其分支的皮质区域灌注不足。
