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非小细胞肺癌患者生活质量的社会人口学和临床决定因素

Sociodemographic and Clinical Determinants of Quality of Life of Patients with Non-small Cell Lung Cancer.

作者信息

Chabowski Mariusz, Polański Jacek, Mazur Grzegorz, Janczak Dariusz, Rosińczuk Joanna

机构信息

Division of Surgical Procedures, Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, 5 Bartla Street, 51-618, Wroclaw, Poland.

Lower Silesian Oncology Center, Home Hospice, 12 Hirszfeld Square, 53-413, Wroclaw, Poland.

出版信息

Adv Exp Med Biol. 2017;1022:1-10. doi: 10.1007/5584_2017_36.

Abstract

Non-small cell lung cancer (NSCLC) is a serious health problem. Identifying factors affecting quality of life (QoL) may help modify risk factors and improve survival. The study included 180 patients treated for NSCLC in the Lower Silesian Center of Lung Diseases between January and December 2015. QoL was assessed with QLQ-C30 and QLQ-LC13 scales. General physical functioning was measured with the ECOG Performance Status scale. The clinical and sociodemographic data were retrieved from medical records. The influence of clinical and sociodemographic factors on QoL was examined. NSCLC reduced the global QoL (47.1 ± 23.4) and emotional functioning (57.8 ± 28.8); cognitive functioning was affected in least (76.0 ± 21.0). The patients reported fatigue (42.2 ± 26.2), sleep problems (42.0 ± 30.8), cough (49.8 ± 24.0), and taking analgesics (50.3 ± 37.1) as the most limiting factors. The worsening of a health condition expressed by the length of malignant disease; the presence of comorbidities, metastases, the cluster of symptoms, worse spirometric indices, and living alone had a negative influence on QoL. In conclusion, patients with NSCLC experience reduced QoL and emotional functioning. Proper treatment of comorbidities and symptom management may improve QoL in these patients.

摘要

非小细胞肺癌(NSCLC)是一个严重的健康问题。识别影响生活质量(QoL)的因素可能有助于改变危险因素并提高生存率。该研究纳入了2015年1月至12月在西里西亚肺部疾病中心接受NSCLC治疗的180例患者。使用QLQ-C30和QLQ-LC13量表评估生活质量。用ECOG体能状态量表测量总体身体功能。从医疗记录中获取临床和社会人口统计学数据。研究了临床和社会人口统计学因素对生活质量的影响。NSCLC降低了总体生活质量(47.1±23.4)和情绪功能(57.8±28.8);认知功能受影响最小(76.0±21.0)。患者报告疲劳(42.2±26.2)、睡眠问题(42.0±30.8)、咳嗽(49.8±24.0)和服用镇痛药(50.3±37.1)是最具限制的因素。以恶性疾病时长表示的健康状况恶化;合并症、转移、症状群、较差的肺功能指标以及独居对生活质量有负面影响。总之,NSCLC患者的生活质量和情绪功能下降。适当治疗合并症和症状管理可能会改善这些患者的生活质量。

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