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[青年猝死与结缔组织发育异常方面的血管病理学:解剖学、生理学及形态学上的相似之处]

[Vascular pathology in the aspect of sudden death in young adults and connective tissue dysplasia: anatomical, physiological, and morphological parallels].

作者信息

Pigolkin Iu I, Shilova M A, Globa I V

机构信息

First Moscow State Medical University named after I.M. Sechenov under the Ministry of Public Health of the Russian Federation, Moscow, Russia.

出版信息

Angiol Sosud Khir. 2017;23(1):36-42.

Abstract

Vascular pathology in young adults has during the last 10 years been diagnosed more often during forensic medical examination of sudden death. Major morphological alterations are revealed in cerebral vessels, coronary vessels, and at the level of the ascending portion of the aorta. Generally, in the young age there is no stenosing atherosclerosis inducing vascular lesions and the development of complications. It was determined that connective tissue dysplasia is pathology wherein weakness of the vascular wall is genetically preconditioned, thus promoting formation of vascular aneurysms and rupture of the latter under conditions of provoking factors such as going in for sports, physical loads, and psychoemotional stress.

摘要

在过去十年中,年轻成年人的血管病变在猝死的法医检查中被诊断出的频率更高。在脑血管、冠状动脉以及主动脉升部水平发现了主要的形态学改变。一般来说,在年轻人群中不存在导致血管病变和并发症发生的狭窄性动脉粥样硬化。已确定结缔组织发育异常是一种病理学状态,其中血管壁的薄弱是由遗传因素预先决定的,因此在诸如从事体育运动、承受体力负荷和心理情绪压力等诱发因素的情况下,会促进血管动脉瘤的形成及其破裂。

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