酶激活还原型笼状 SERS 报告分子用于多功能生物测定。
Enzymatically activated reduction-caged SERS reporters for versatile bioassays.
机构信息
Department of Biomedical Engineering, College of Engineering and Applied Sciences, Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing, Jiangsu 210093, China.
出版信息
Analyst. 2017 Jun 26;142(13):2322-2326. doi: 10.1039/c7an00552k.
Here we report a facile strategy for activating reduction caged Raman reporters for surface-enhanced Raman scattering (SERS) with peroxidases. After selecting suitable caged reporters, versatile bioassays were developed. First, the bioassays for bioactive small molecules were developed. Then, the immunoassay was developed for C reactive protein (CRP), a biomarker for cardiovascular diseases.
在这里，我们报告了一种简便的策略，用于通过过氧化物酶激活还原笼状拉曼报告分子以进行表面增强拉曼散射（SERS）。在选择合适的笼状报告分子后，开发了多种生物分析方法。首先，开发了用于生物活性小分子的生物分析方法。然后，开发了用于心血管疾病生物标志物 C 反应蛋白（CRP）的免疫分析方法。
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