Jia Min, Li Shenmiao, Zang Liguo, Lu Xiaonan, Zhang Hongyan
Shandong Provincial Key Laboratory of Animal Resistance Biology, Institute of Biomedical Sciences, Key Laboratory of Food Nutrition and Safety of Shandong Normal University, College of Life Science, Shandong Normal University, Jinan 250014, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China.
Nanomaterials (Basel). 2018 Sep 15;8(9):730. doi: 10.3390/nano8090730.
Analyzing biomolecules is essential for disease diagnostics, food safety inspection, environmental monitoring and pharmaceutical development. Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for detecting biomolecules due to its high sensitivity, rapidness and specificity in identifying molecular structures. This review focuses on the SERS analysis of biomolecules originated from humans, animals, plants and microorganisms, combined with nanomaterials as SERS substrates and nanotags. Recent advances in SERS detection of target molecules were summarized with different detection strategies including label-free and label-mediated types. This comprehensive and critical summary of SERS analysis of biomolecules might help researchers from different scientific backgrounds spark new ideas and proposals.
分析生物分子对于疾病诊断、食品安全检测、环境监测和药物研发至关重要。表面增强拉曼光谱（SERS）因其在识别分子结构方面的高灵敏度、快速性和特异性，是检测生物分子的有力工具。本综述聚焦于源自人类、动物、植物和微生物的生物分子的SERS分析，以及作为SERS基底和纳米标签的纳米材料。总结了SERS检测目标分子的最新进展，包括无标记和标记介导类型等不同检测策略。对生物分子SERS分析的这一全面且关键的总结可能有助于不同科学背景的研究人员激发新的想法和建议。
