Miller Stacey D, Juricic Maria, Hesketh Kim, Mclean Lynore, Magnuson Sonja, Gasior Sherylin, Schaeffer Emily, O'donnell Maureen, Mulpuri Kishore
BC Children's Hospital, Vancouver, BC, Canada.
Closing the Gap Health Care Group, Barrie, ON, Canada.
Dev Med Child Neurol. 2017 Nov;59(11):1130-1138. doi: 10.1111/dmcn.13480. Epub 2017 Jun 2.
To conduct a systematic review and evaluate the quality of evidence for interventions to prevent hip displacement in children with cerebral palsy (CP).
A systematic review was performed using American Academy of Cerebral Palsy and Developmental Medicine (AACPDM) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. Searches were completed in seven electronic databases. Studies were included if participants had CP and the effectiveness of the intervention was reported using a radiological measure. Results of orthopaedic surgical interventions were excluded.
Twenty-four studies fulfilled the inclusion criteria (4 botulinum neurotoxin A; 2 botulinum neurotoxin A and bracing; 1 complementary and alternative medicine; 1 intrathecal baclofen; 1 obturator nerve block; 8 positioning; 7 selective dorsal rhizotomy). There was significant variability in treatment dosages, participant characteristics, and duration of follow-up among the studies. Overall, the level of evidence was low. No intervention in this review demonstrated a large treatment effect on hip displacement.
The level and quality of evidence for all interventions aimed at slowing or preventing hip displacement is low. There is currently insufficient evidence to support or refute the use of the identified interventions to prevent hip displacement or dislocation in children and young people with CP.
High-quality evidence on prevention of hip displacement is lacking. No recommendations can be made for preventing hip displacement in children with cerebral palsy because of poor-quality evidence. High-quality, prospective, longitudinal studies investigating the impact of interventions on hip displacement are required.
进行一项系统评价并评估预防脑瘫(CP)患儿髋关节脱位干预措施的证据质量。
采用美国脑性瘫痪和发育医学学会(AACPDM)及系统评价与Meta分析的首选报告项目(PRISMA)方法进行系统评价。在七个电子数据库中完成检索。如果参与者患有CP且使用放射学测量报告了干预措施的有效性,则纳入研究。排除骨科手术干预的结果。
24项研究符合纳入标准(4项肉毒杆菌神经毒素A;2项肉毒杆菌神经毒素A与支具;1项补充和替代医学;1项鞘内注射巴氯芬;1项闭孔神经阻滞;8项体位摆放;7项选择性背根切断术)。各项研究在治疗剂量、参与者特征和随访持续时间方面存在显著差异。总体而言,证据水平较低。本评价中没有干预措施对髋关节脱位显示出显著的治疗效果。
所有旨在减缓或预防髋关节脱位的干预措施的证据水平和质量都很低。目前没有足够的证据支持或反驳使用已确定的干预措施来预防CP患儿和青少年的髋关节脱位。
缺乏关于预防髋关节脱位的高质量证据。由于证据质量差,无法对预防脑瘫患儿髋关节脱位提出建议。需要开展高质量的前瞻性纵向研究,以调查干预措施对髋关节脱位的影响。