线粒体衍生肽作为代谢的新型调节剂。
Mitochondrially derived peptides as novel regulators of metabolism.
机构信息
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
出版信息
J Physiol. 2017 Nov 1;595(21):6613-6621. doi: 10.1113/JP274472. Epub 2017 Jul 18.
Abstract
Mitochondrially derived peptides represent a new class of circulating signalling molecules. Humanin, the first member of this class, has been shown to have several metabolic effects such as reducing weight gain and visceral fat and increasing glucose-stimulated insulin release. The discovery of several other new members, such as MOTS-c and SHLP1-6, has further added to this group. These new peptides have also been found to affect metabolism with MOTS-c potently decreasing weight gain in mice on a high-fat diet. This review covers the basic biology of this class of peptides and discusses the relevance to organismal metabolism.
摘要
线粒体衍生肽代表了一类新的循环信号分子。作为该类别的第一个成员，神经调节蛋白已经显示出多种代谢作用，如减少体重增加和内脏脂肪，以及增加葡萄糖刺激的胰岛素释放。其他几个新成员的发现，如 MOTS-c 和 SHLP1-6，进一步增加了这个群体。这些新的肽也被发现影响代谢，MOTS-c 能强烈减少高脂肪饮食小鼠的体重增加。这篇综述涵盖了这类肽的基础生物学，并讨论了它们与机体代谢的相关性。
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