Pontello Rubens, Kondo Rogério Nabor, Pavezzi Priscila Daiane, Nicolacopulos Theo, Kippert Julia Pagung, Lena Clarissa
Dermatology service, State University of Londrina (UEL), Londrina, Paraná, Brazil.
Resident physician of dermatology, State University of Londrina (UEL), Londrina, Paraná, Brazil.
J Cosmet Dermatol. 2018 Apr;17(2):152-156. doi: 10.1111/jocd.12364. Epub 2017 Jun 2.
Facial filling with hyaluronic acid (HA) is a dermatological procedure that has been emerging today. There are not many references regarding safety of reusing the remaining product for later touch-up in the same patient.
To determine the microbiological safety of reusing hyaluronic acid that is remnant from syringes used for facial filling, stored at room temperature or cooled in a refrigerator at 4°C.
In culture medium, small aliquots of leftovers from 31 hyaluronic acid fillers, previously used for facial filling, were inoculated. The fillers were stored in their original syringes at room temperature or cooled in a standard refrigerator at 4°C for a period ranging from 1 week to 12 months after initial use.
The small number of samples limits extrapolation of the results obtained.
After 42 days of inoculation in culture medium, none of the samples showed any aerobic or anaerobic bacterial or fungal growth.
Hyaluronic acid fillers did not show any fungal or bacterial contamination after being opened and stored at room temperature in nonaseptic conditions. The possibility of reusing the remaining portion of the material in the syringe can be safe and economically viable.
透明质酸（HA）面部填充是当下一种新兴的皮肤科手术。关于在同一患者后续补妆时重复使用剩余产品的安全性，相关参考文献并不多。
确定重复使用用于面部填充的注射器中剩余的透明质酸的微生物安全性，这些剩余透明质酸在室温下储存或在4°C冰箱中冷藏。
在培养基中接种了31种先前用于面部填充的透明质酸填充剂的小份剩余物。这些填充剂在初次使用后的1周内至12个月期间，保存在其原注射器中，分别置于室温或标准冰箱中4°C冷藏。
样本数量较少限制了所得结果的外推。
在培养基中接种42天后，所有样本均未显示出任何需氧或厌氧细菌或真菌生长。
透明质酸填充剂在非无菌条件下于室温下开封并储存后，未显示出任何真菌或细菌污染。重复使用注射器中剩余材料可能是安全且经济可行的。
