Bellew Supriya G, Carroll Karen C, Weiss Margaret A, Weiss Robert A
Maryland Laser, Skin and Vein Institute, Hunt Valley, Maryland 21030, USA.
J Am Acad Dermatol. 2005 Jun;52(6):988-90. doi: 10.1016/j.jaad.2005.01.131.
Restylane (Restylane; Q-Medical, Uppsala, Sweden) is a nonanimal stabilized hyaluronic acid (NASHA) that has become increasingly popular for soft tissue augmentation and volume correction because of its greater longevity and lower rate of hypersensitivity reactions when compared with collagen. Despite manufacturer warnings, the remaining material in the syringe is commonly stored for subsequent treatment in the same patient.
Our purpose was to determine the incidence of bacterial contamination of NASHA stored after initial patient injection.
After use of a specific sterile sequence, NASHA from previously used syringes stored at room temperature for 2 to 9 months was cultured under aerobic (n = 20) and anaerobic conditions (n = 10).
No bacteria were cultured from any of the samples.
Limitations of this study include sample size and storage period for a maximum of 9 months.
NASHA remaining in syringes after patient injection was not contaminated with bacteria. Our study raises the possibility that re-use of the remaining portion of material in the syringe may be safe and is more economical than discarding it.
瑞蓝（Restylane；Q-Medical，瑞典乌普萨拉）是一种非动物源稳定透明质酸（NASHA），与胶原蛋白相比，因其具有更长的维持时间和更低的过敏反应发生率，在软组织填充和容积矫正方面越来越受欢迎。尽管制造商有警告，但注射器中剩余的材料通常会被储存起来用于同一患者的后续治疗。
我们的目的是确定初次注射后储存的NASHA细菌污染的发生率。
按照特定的无菌操作流程，将先前使用过的注射器中在室温下储存2至9个月的NASHA进行需氧培养（n = 20）和厌氧培养（n = 10）。
所有样本均未培养出细菌。
本研究的局限性包括样本量和最长9个月的储存期。
患者注射后注射器中剩余的NASHA未被细菌污染。我们的研究提出了注射器中剩余材料再利用可能是安全的，且比丢弃更经济的可能性。
