采用无丝氨酸和甘氨酸饮食疗法利用肿瘤依赖性 - Suppr

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Exploiting tumour addiction with a serine and glycine-free diet.

作者信息

Amelio Ivano, Melino Gerry, Frezza Christian

机构信息

MRC Toxicology Unit, Leicester, UK.

Department Experimental Medicine &Surgery, University Rome Tor Vergata, Rome, Italy.

出版信息

Cell Death Differ. 2017 Aug;24(8):1311-1313. doi: 10.1038/cdd.2017.83. Epub 2017 Jun 2.

DOI:10.1038/cdd.2017.83

PMID:28574507

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5520463/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4825/5520463/14c30351851e/cdd201783f1.jpg

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LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.

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Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition.

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Metabolic reprogramming during neuronal differentiation.

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The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression.

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相似文献

Exploiting tumour addiction with a serine and glycine-free diet.

Cell Death Differ. 2017 Aug;24(8):1311-1313. doi: 10.1038/cdd.2017.83. Epub 2017 Jun 2.

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Influence of dietary glycine and serine on lipid metabolism in the rat in folic acid deficiency.

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Cell Rep. 2024 Aug 27;43(8):114552. doi: 10.1016/j.celrep.2024.114552. Epub 2024 Jul 27.

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本文引用的文献

Modulating the therapeutic response of tumours to dietary serine and glycine starvation.

Nature. 2017 Apr 19;544(7650):372-376. doi: 10.1038/nature22056.

Serine Is an Essential Metabolite for Effector T Cell Expansion.

Cell Metab. 2017 Feb 7;25(2):345-357. doi: 10.1016/j.cmet.2016.12.011. Epub 2017 Jan 19.

Fumarate drives EMT in renal cancer.

Cell Death Differ. 2017 Jan;24(1):1-2. doi: 10.1038/cdd.2016.137. Epub 2016 Nov 25.

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.

Nature. 2016 Nov 17;539(7629):390-395. doi: 10.1038/nature20132. Epub 2016 Oct 31.

Serine and one-carbon metabolism in cancer.

Nat Rev Cancer. 2016 Oct;16(10):650-62. doi: 10.1038/nrc.2016.81. Epub 2016 Sep 16.

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition.

Nature. 2016 Aug 31;537(7621):544-547. doi: 10.1038/nature19353.

Metabolic reprogramming during neuronal differentiation.

Cell Death Differ. 2016 Sep 1;23(9):1502-14. doi: 10.1038/cdd.2016.36. Epub 2016 Apr 8.

NRF2 regulates serine biosynthesis in non-small cell lung cancer.

Nat Genet. 2015 Dec;47(12):1475-81. doi: 10.1038/ng.3421. Epub 2015 Oct 19.

The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression.

Trends Biochem Sci. 2015 Aug;40(8):425-34. doi: 10.1016/j.tibs.2015.04.007. Epub 2015 May 29.

Serine and glycine metabolism in cancer.

Trends Biochem Sci. 2014 Apr;39(4):191-8. doi: 10.1016/j.tibs.2014.02.004. Epub 2014 Mar 20.