Laboratory of Preclinical and Translational Research, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), 85028 Rionero in Vulture, PZ, Italy.
Laboratory of Preclinical and Translational Research, Responsible Research Hospital, 86100 Campobasso, CB, Italy.
Int J Mol Sci. 2024 Feb 27;25(5):2750. doi: 10.3390/ijms25052750.
Inflammation is a key contributor to both the initiation and progression of tumors, and it can be triggered by genetic instability within tumors, as well as by lifestyle and dietary factors. The inflammatory response plays a critical role in the genetic and epigenetic reprogramming of tumor cells, as well as in the cells that comprise the tumor microenvironment. Cells in the microenvironment acquire a phenotype that promotes immune evasion, progression, and metastasis. We will review the mechanisms and pathways involved in the interaction between tumors, inflammation, and nutrition, the limitations of current therapies, and discuss potential future therapeutic approaches.
炎症是肿瘤发生和发展的关键因素，它可以由肿瘤内的遗传不稳定性以及生活方式和饮食因素引发。炎症反应在肿瘤细胞的遗传和表观遗传重编程中以及构成肿瘤微环境的细胞中发挥着关键作用。微环境中的细胞获得了促进免疫逃逸、进展和转移的表型。我们将回顾肿瘤、炎症和营养之间相互作用涉及的机制和途径、当前疗法的局限性，并讨论潜在的未来治疗方法。
Zotero 插件
