佛波酯对神经传递的影响：与平滑肌中神经递质和钙的相互作用
Phorbol ester effects on neurotransmission: interaction with neurotransmitters and calcium in smooth muscle.
作者信息
Baraban J M, Gould R J, Peroutka S J, Snyder S H
出版信息
Proc Natl Acad Sci U S A. 1985 Jan;82(2):604-7. doi: 10.1073/pnas.82.2.604.
Abstract
Stimulation of the phosphatidylinositol cycle by neurotransmitters generates diacylglycerol, an activator of protein kinase C, which may regulate some forms of neurotransmission. Phorbol esters, potent inflammatory and tumor-promoting compounds, also activate protein kinase C. We demonstrate potent and selective effects of phorbol esters on smooth muscle, indicating a role for protein kinase C in neurotransmission. In rat vas deferens and dog basilar artery, phorbol esters synergize with calcium to mimic the contractile effects of neurotransmitters that act through the phosphatidylinositol cycle. In guinea pig ileum and rat uterus, phorbol esters block contractions produced by these neurotransmitters.
摘要
神经递质对磷脂酰肌醇循环的刺激会产生二酰基甘油，它是蛋白激酶C的激活剂，可能调节某些形式的神经传递。佛波酯是强效的炎症促进剂和肿瘤促进化合物，也能激活蛋白激酶C。我们证明了佛波酯对平滑肌有强效且选择性的作用，表明蛋白激酶C在神经传递中发挥作用。在大鼠输精管和犬基底动脉中，佛波酯与钙协同作用，模拟通过磷脂酰肌醇循环起作用的神经递质的收缩效应。在豚鼠回肠和大鼠子宫中，佛波酯可阻断这些神经递质产生的收缩。
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