Menkes H A, Baraban J M, Freed A N, Snyder S H
Proc Natl Acad Sci U S A. 1986 Aug;83(15):5727-30. doi: 10.1073/pnas.83.15.5727.
Lithium, by inhibiting inositol phosphate metabolism, interferes with the phosphatidylinositol ("phosphoinositide") cycle, which is stimulated by numerous hormones and neurotransmitters. To examine the relevance of this action to neurotransmission, we evaluated effects of lithium treatment on smooth muscle responses to transmitters. In lithium-pretreated tracheal muscle, the relaxation following carbachol or histamine contractions is retarded. Lithium does not affect relaxation following contractions elicited by treatment with KCl and phorbol 12,13-diacetate in combination, which bypasses receptor stimulation of the phosphatidylinositol cycle. Half-maximal effects of lithium occur at 1 mM, corresponding to therapeutic concentrations. Dampening of neurotransmitter responses by lithium treatment may explain the unique ability of lithium to relieve and prevent both mania and depression.
锂通过抑制肌醇磷酸代谢，干扰磷脂酰肌醇（“磷酸肌醇”）循环，而该循环受多种激素和神经递质刺激。为研究此作用与神经传递的相关性，我们评估了锂治疗对平滑肌对递质反应的影响。在经锂预处理的气管平滑肌中，卡巴胆碱或组胺收缩后的舒张作用延迟。锂不影响氯化钾和佛波醇12,13 - 二乙酸酯联合处理引发的收缩后的舒张，后者绕过了受体对磷脂酰肌醇循环的刺激。锂的半数最大效应出现在1 mM，这与治疗浓度相对应。锂治疗对神经递质反应的抑制可能解释了锂缓解和预防躁狂和抑郁的独特能力。
