CXCL1-CXCR2轴在胃癌肿瘤微环境中的临床病理意义
Clinicopathologic significance of the CXCL1-CXCR2 axis in the tumor microenvironment of gastric carcinoma.
作者信息
Kasashima Hiroaki, Yashiro Masakazu, Nakamae Hirohisa, Masuda Go, Kinoshita Haruhito, Morisaki Tamami, Fukuoka Tatsunari, Hasegawa Tsuyoshi, Nakane Takahiko, Hino Masayuki, Hirakawa Kosei, Ohira Masaichi
机构信息
Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Molecular Oncology and Therapeutics, Osaka City University Graduate School of Medicine, Osaka, Japan.
出版信息
PLoS One. 2017 Jun 2;12(6):e0178635. doi: 10.1371/journal.pone.0178635. eCollection 2017.
PURPOSE
It was reported that the chemokine (C-X-C motif) ligand 1 (CXCL1) from cancer cells stimulated the recruitment of bone marrow-derived mesenchymal cells (BM-MCs) into tumor stroma via chemokine (C-X-C motif) receptor 2 (CXCR2) signaling. We conducted this retrospective study to determine the clinicopathologic significance of the CXCL1-CXCR2 axis in human gastric cancer.
METHODS
The correlations between the clinicopathological features of 270 primary gastric carcinomas and CXCL1 in cancer cells and CXCR2 in stromal cells were analyzed in immunohistochemical studies. The effect of gastric cancer cells on the expression of CXCR2 in BM-MCs was examined using diffuse-type gastric cancer cell lines in vitro.
RESULTS
The expression of CXCL1 in cancer cells was correlated with T invasion (T2-T4), lymph node metastasis, lymphatic invasion, venous invasion, peritoneal cytology, peritoneal metastasis and CXCR2 expression in stromal cells. The expression of CXCR2 in stromal cells was correlated with macroscopic type-4 cancers, histological type, T invasion (T2-T4), lymph node metastasis, lymphatic invasion, infiltration, peritoneal cytology, peritoneal metastasis and CD271 expression in stromal cells. The overall survival of patients with CXCL1 and CXCR2-positive cancer was poorer than that of the patients with negative cancer. Both CXCL1 expression in cancer cells and CXCR2 expression in stromal cells were independent prognostic factors for gastric cancer patients.
CONCLUSION
The expressions of CXCL1 in cancer cells and CXCR2 in stromal cells are useful prognostic factors for gastric cancer patients.
目的
据报道，癌细胞分泌的趋化因子（C-X-C基序）配体1（CXCL1）通过趋化因子（C-X-C基序）受体2（CXCR2）信号通路刺激骨髓来源的间充质细胞（BM-MCs）募集至肿瘤基质。我们开展这项回顾性研究以确定CXCL1-CXCR2轴在人胃癌中的临床病理意义。
方法
在免疫组化研究中分析270例原发性胃癌的临床病理特征与癌细胞中CXCL1及基质细胞中CXCR2之间的相关性。使用弥漫型胃癌细胞系在体外检测胃癌细胞对BM-MCs中CXCR2表达的影响。
结果
癌细胞中CXCL1的表达与T分期（T2-T4）、淋巴结转移、淋巴管浸润、静脉浸润、腹腔细胞学检查、腹膜转移及基质细胞中CXCR2的表达相关。基质细胞中CXCR2的表达与大体类型为4型的癌症、组织学类型、T分期（T2-T4）、淋巴结转移、淋巴管浸润、浸润深度、腹腔细胞学检查、腹膜转移及基质细胞中CD271的表达相关。CXCL1和CXCR2阳性癌症患者的总生存期比阴性癌症患者差。癌细胞中CXCL1的表达和基质细胞中CXCR2的表达均为胃癌患者的独立预后因素。
结论
癌细胞中CXCL1的表达和基质细胞中CXCR2的表达是胃癌患者有用的预后因素。
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