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生长抑素对人生长激素及催乳素对皮啡肽反应的影响。

Effect of somatostatin on growth hormone and prolactin response to dermorphin in man.

作者信息

degli Uberti E C, Trasforini G, Salvadori S, Margutti A, Teodori V, Rotola C, Tomatis R, Pansini R

出版信息

Acta Endocrinol (Copenh). 1985 Jan;108(1):20-5. doi: 10.1530/acta.0.1080020.

DOI:10.1530/acta.0.1080020
PMID:2857511
Abstract

The effects of iv somatostatin (somatotrophin release inhibiting factor (SRIF) on growth hormone (GH) and prolactin (Prl) response to dermorphin (D) were tested in 6 healthy men. In all subjects D induced a significant increase in GH and Prl levels, as expected. SRIF completely blocked the GH-releasing activity of D, whereas it only reduced the Prl-releasing activity. The results confirm that D is a potent stimulant for GH and Prl release in man, and furthermore demonstrate that the action of D on GH secretion can be completely overridden by SRIF.

摘要

在6名健康男性中测试了静脉注射生长抑素(促生长激素释放抑制因子(SRIF))对生长激素(GH)和催乳素(Prl)对德莫啡肽(D)反应的影响。如预期的那样,在所有受试者中,D均导致GH和Prl水平显著升高。SRIF完全阻断了D的GH释放活性,而仅降低了Prl释放活性。结果证实,D是人体中GH和Prl释放的有效刺激物,并且进一步证明SRIF可以完全抑制D对GH分泌的作用。

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