人源中强啡肽诱导生长激素分泌中的胆碱能介导作用。
Cholinergic mediation in dermorphin-induced growth hormone secretion in man.
作者信息
degli Uberti E C, Trasforini G, Salvadori S, Margutti A, Bianconi M, Teodori V, Tomatis R, Pansini R
出版信息
Horm Res. 1986;24(4):251-5. doi: 10.1159/000180564.
PMID:3781483
Abstract
The effects of pirenzepine (P), a cholinergic muscarinic antagonist, on growth hormone (GH) and prolactin (PRL) response to dermorphin (D) were studied in a group of 7 healthy men. D produced clear elevations in GH and PRL levels. P completely blocked the GH-releasing activity of D, whereas it did not alter the PRL-releasing activity. These results indicate that GH-releasing action of D is mediated via the central cholinergic nervous system in man.
摘要
在7名健康男性中研究了毒蕈碱型胆碱能拮抗剂哌仑西平（P）对生长激素（GH）和催乳素（PRL）对皮啡肽（D）反应的影响。D使GH和PRL水平明显升高。P完全阻断了D的GH释放活性，而未改变PRL释放活性。这些结果表明，在人类中，D的GH释放作用是通过中枢胆碱能神经系统介导的。
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