Marubashi S, Tominaga M, Katagiri T, Yamatani K, Yawata Y, Hara M, Sasaki H
Acta Endocrinol (Copenh). 1985 Jan;108(1):6-10. doi: 10.1530/acta.0.1080006.
The intracerebroventricular (icv) administration of 100 ng glucagon resulted in more prolonged and pronounced elevations of plasma glucose levels than the intravenous injection of 100 ng glucagon. Insignificant changes in plasma IRI and IRG levels after icv glucagon administration contrasted to marked increases in both IRI and IRG levels after the iv injection. Icv glucagon-induced hyperglycaemia was completely prevented by the prior administration of atropine, phentolamine or hexamethonium, and partially inhibited by bilateral adrenalectomy, but not by propranolol pretreatment. These findings suggested that the hyperglycaemic effect is brought about through cholinergic and alpha-adrenergic neural pathways and partly via the adrenal medulla.
脑室内（icv）注射100 ng胰高血糖素比静脉注射100 ng胰高血糖素导致血浆葡萄糖水平升高更持久、更显著。脑室内注射胰高血糖素后血浆胰岛素释放肽（IRI）和胰岛素受体底物-葡萄糖（IRG）水平无明显变化，与静脉注射后IRI和IRG水平显著升高形成对比。预先给予阿托品、酚妥拉明或六甲铵可完全阻止脑室内注射胰高血糖素诱导的高血糖，双侧肾上腺切除可部分抑制该效应，但普萘洛尔预处理则无此作用。这些发现表明，高血糖效应是通过胆碱能和α-肾上腺素能神经通路以及部分通过肾上腺髓质实现的。
