Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee, USA.
Nat Med. 2013 Jun;19(6):674-5. doi: 10.1038/nm.3202.
New insights into the actions of the hormone glucagon are provided by a recent study in rodents, which shows that glucagon can suppress hepatic glucose production by acting through the mediobasal hypothalamic region of the brain. This central regulatory mechanism is impaired in rats fed a high-fat diet, suggesting that hypothalamic glucagon resistance may be relevant to the hyperglycemia observed in obesity, diabetes or both (pages 766–772).
最近一项针对啮齿动物的研究为激素胰高血糖素的作用提供了新的见解，该研究表明，胰高血糖素可以通过作用于大脑的中基底下丘脑区域来抑制肝葡萄糖生成。这种中枢调节机制在高脂饮食喂养的大鼠中受损，这表明下丘脑胰高血糖素抵抗可能与肥胖、糖尿病或两者都观察到的高血糖有关（第 766-772 页）。
