非侵入性神经调节深入探究。
Noninvasive Neuromodulation Goes Deep.
作者信息
Dmochowski Jacek, Bikson Marom
机构信息
Department of Biomedical Engineering, The City College of New York of CUNY, New York, NY 10031, USA.
Department of Biomedical Engineering, The City College of New York of CUNY, New York, NY 10031, USA.
出版信息
Cell. 2017 Jun 1;169(6):977-978. doi: 10.1016/j.cell.2017.05.017.
Abstract
Modulating deep regions of the brain with noninvasive technology has challenged researchers for decades. In a new study, Grossman et al. leverage the emergence of a slowly oscillating "beat" from intersecting high-frequency electric fields to stimulate deep brain regions, opening a frontier in the biophysics and technology of brain stimulation.
摘要
几十年来，利用非侵入性技术调节大脑深部区域一直是研究人员面临的挑战。在一项新研究中，格罗斯曼等人利用相交高频电场产生的缓慢振荡“节拍”来刺激大脑深部区域，开启了脑刺激生物物理学和技术的新领域。
相似文献
1
Noninvasive Neuromodulation Goes Deep.非侵入性神经调节深入探究。
Cell. 2017 Jun 1;169(6):977-978. doi: 10.1016/j.cell.2017.05.017.
2
Neuromodulation for depression: invasive and noninvasive (deep brain stimulation, transcranial magnetic stimulation, trigeminal nerve stimulation).抑郁症的神经调节：有创和无创（脑深部电刺激、经颅磁刺激、三叉神经刺激）。
Neurosurg Clin N Am. 2014 Jan;25(1):103-16. doi: 10.1016/j.nec.2013.10.002.
3
High-permeability core coils for transcranial magnetic stimulation of deep brain regions.
Annu Int Conf IEEE Eng Med Biol Soc. 2007;2007:6653-6. doi: 10.1109/IEMBS.2007.4353885.
4
Magnetic temporal interference for noninvasive and focal brain stimulation.用于无创和局灶性脑刺激的磁颞干扰。
J Neural Eng. 2023 Jan 18;20(1). doi: 10.1088/1741-2552/acb015.
5
Brain Neuromodulation Techniques: A Review.脑神经调节技术：综述
Neuroscientist. 2016 Aug;22(4):406-21. doi: 10.1177/1073858416646707. Epub 2016 Apr 29.
6
Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields.通过时间干扰电场进行无创深部脑刺激
Cell. 2017 Jun 1;169(6):1029-1041.e16. doi: 10.1016/j.cell.2017.05.024.
7
Noninvasive and invasive neuromodulation for the treatment of tinnitus: an overview.非侵入性和侵入性神经调节治疗耳鸣：概述。
Neuromodulation. 2012 Jul;15(4):350-60. doi: 10.1111/j.1525-1403.2012.00447.x. Epub 2012 Apr 11.
8
Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity.用于研究饮食行为以及预防和治疗饮食失调与肥胖症的神经影像学和神经调节方法。
Neuroimage Clin. 2015 Mar 24;8:1-31. doi: 10.1016/j.nicl.2015.03.016. eCollection 2015.
9
Opportunities of connectomic neuromodulation.连接组神经调节的机会。
Neuroimage. 2020 Nov 1;221:117180. doi: 10.1016/j.neuroimage.2020.117180. Epub 2020 Jul 20.
10
Linking invasive and noninvasive neuromodulation techniques to study network properties of the brain.
Clin Neurophysiol. 2019 Apr;130(4):548-549. doi: 10.1016/j.clinph.2018.12.006. Epub 2019 Jan 18.
引用本文的文献
1
Advances in the application of temporal interference stimulation: a scoping review.时间干扰刺激应用的进展：一项范围综述
Front Hum Neurosci. 2025 May 30;19:1536906. doi: 10.3389/fnhum.2025.1536906. eCollection 2025.
2
Advances in non-invasive brain stimulation: enhancing sports performance function and insights into exercise science.非侵入性脑刺激的进展：增强运动表现功能及对运动科学的见解
Front Hum Neurosci. 2024 Nov 29;18:1477111. doi: 10.3389/fnhum.2024.1477111. eCollection 2024.
3
Cell-specific effects of temporal interference stimulation on cortical function.时程干扰刺激对皮质功能的细胞特异性影响。
Commun Biol. 2024 Sep 2;7(1):1076. doi: 10.1038/s42003-024-06728-y.
4
Quasistatic approximation in neuromodulation.神经调节中的准静态近似。
J Neural Eng. 2024 Jul 24;21(4). doi: 10.1088/1741-2552/ad625e.
5
Noninvasive Deep Brain Stimulation via Temporal Interference Electric Fields Enhanced Motor Performance of Mice and Its Neuroplasticity Mechanisms.经颞部干扰电场的无创性脑深部电刺激增强了小鼠的运动表现及其神经可塑性机制。
Mol Neurobiol. 2024 Jun;61(6):3314-3329. doi: 10.1007/s12035-023-03721-0. Epub 2023 Nov 21.
6
A novel non-invasive brain stimulation technique: "Temporally interfering electrical stimulation".一种新型非侵入性脑刺激技术：“时间干扰电刺激”。
Front Neurosci. 2023 Jan 27;17:1092539. doi: 10.3389/fnins.2023.1092539. eCollection 2023.
7
Responses of model cortical neurons to temporal interference stimulation and related transcranial alternating current stimulation modalities.模型皮质神经元对时频干扰刺激及相关经颅交流电刺激模式的反应。
J Neural Eng. 2023 Jan 3;19(6). doi: 10.1088/1741-2552/acab30.
8
Safety Evaluation of Employing Temporal Interference Transcranial Alternating Current Stimulation in Human Studies.人类研究中使用颞叶干扰经颅交流电刺激的安全性评估。
Brain Sci. 2022 Sep 5;12(9):1194. doi: 10.3390/brainsci12091194.
9
Limited Sensitivity of Hippocampal Synaptic Function or Network Oscillations to Unmodulated Kilohertz Electric Fields.千赫兹电场未经调制时对海马突触功能或网络振荡的敏感性有限。
eNeuro. 2020 Dec 16;7(6). doi: 10.1523/ENEURO.0368-20.2020. Print 2020 Nov-Dec.
10
Temporal interference stimulation targets deep brain regions by modulating neural oscillations.时程干扰刺激通过调节神经振荡来靶向深部脑区。
Brain Stimul. 2021 Jan-Feb;14(1):55-65. doi: 10.1016/j.brs.2020.11.007. Epub 2020 Nov 11.
本文引用的文献
1
Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields.通过时间干扰电场进行无创深部脑刺激
Cell. 2017 Jun 1;169(6):1029-1041.e16. doi: 10.1016/j.cell.2017.05.024.
2
Measurements and models of electric fields in the human brain during transcranial electric stimulation.经颅电刺激期间人脑电场的测量与模型
Elife. 2017 Feb 7;6:e18834. doi: 10.7554/eLife.18834.
3
Spatiotemporal structure of intracranial electric fields induced by transcranial electric stimulation in humans and nonhuman primates.经颅电刺激在人类和非人类灵长类动物中诱发的颅内电场的时空结构。
Sci Rep. 2016 Aug 18;6:31236. doi: 10.1038/srep31236.
4
Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016.经颅直流电刺激的安全性：2016年循证更新
Brain Stimul. 2016 Sep-Oct;9(5):641-661. doi: 10.1016/j.brs.2016.06.004. Epub 2016 Jun 15.
5
Modeling transcranial electric stimulation in mouse: a high resolution finite element study.小鼠经颅电刺激建模：一项高分辨率有限元研究。
Annu Int Conf IEEE Eng Med Biol Soc. 2014;2014:406-9. doi: 10.1109/EMBC.2014.6943614.
6
Inter-Individual Variation during Transcranial Direct Current Stimulation and Normalization of Dose Using MRI-Derived Computational Models.经 MRI 衍生计算模型的经颅直流电刺激中的个体间变异性和剂量归一化。
Front Psychiatry. 2012 Oct 22;3:91. doi: 10.3389/fpsyt.2012.00091. eCollection 2012.
7
Optimized multi-electrode stimulation increases focality and intensity at target.优化的多电极刺激可提高目标部位的聚焦性和强度。
J Neural Eng. 2011 Aug;8(4):046011. doi: 10.1088/1741-2560/8/4/046011. Epub 2011 Jun 10.
8
Gyri-precise head model of transcranial direct current stimulation: improved spatial focality using a ring electrode versus conventional rectangular pad.经颅直流电刺激的脑回精确头模型：使用环形电极而非传统矩形电极垫提高空间聚焦度。
Brain Stimul. 2009 Oct;2(4):201-7, 207.e1. doi: 10.1016/j.brs.2009.03.005.
9
Sensitivity of coherent oscillations in rat hippocampus to AC electric fields.大鼠海马体中相干振荡对交流电场的敏感性。
J Physiol. 2007 Sep 1;583(Pt 2):555-65. doi: 10.1113/jphysiol.2007.137711. Epub 2007 Jun 28.
10
Effects of uniform extracellular DC electric fields on excitability in rat hippocampal slices in vitro.均匀细胞外直流电场对体外培养的大鼠海马脑片兴奋性的影响。
J Physiol. 2004 May 15;557(Pt 1):175-90. doi: 10.1113/jphysiol.2003.055772. Epub 2004 Feb 20.
Zotero 插件