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初乳经口咽给药可提高极低出生体重儿唾液分泌型IgA水平。

Oropharyngeal Administration of Colostrum Increases Salivary Secretory IgA Levels in Very Low-Birth-Weight Infants.

作者信息

Glass Kristen M, Greecher Coleen P, Doheny Kim K

机构信息

Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

出版信息

Am J Perinatol. 2017 Dec;34(14):1389-1395. doi: 10.1055/s-0037-1603655. Epub 2017 Jun 2.

DOI:10.1055/s-0037-1603655
PMID:28575910
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5685905/
Abstract

AIM

Oropharyngeal administration of colostrum (OAC) has been proposed to provide mother's early milk to very low-birth-weight (VLBW) infants in the first few days of life. The aim of this study was to test the hypothesis that OAC would increase salivary secretory IgA (SsIgA).

METHODS

Overall, 30 VLBW infants randomized to receive OAC or sterile water had salivary sampling for SsIgA on the day of life (DOL) 2,7, and 14. The incidence of late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) was determined prospectively. Within and between-group comparisons were made by paired and independent samples -tests.

RESULTS

Baseline characteristics were similar between groups. SsIgA was higher in OAC versus the control group ( < 0.05) on DOL 7, but not subsequently on DOL 14. There was no difference in LOS or NEC.

CONCLUSION

OAC increased SsIgA at DOL 7. A large, multicenter trial is needed to determine if OAC decreases LOS or NEC in VLBW infants.

摘要

目的

有人提出经口咽给予初乳（OAC）可为极低出生体重（VLBW）婴儿在出生后的头几天提供母亲的初乳。本研究的目的是检验OAC会增加唾液分泌型IgA（SsIgA）这一假设。

方法

总体而言，30名随机接受OAC或无菌水的VLBW婴儿在出生日（DOL）2、7和14进行了唾液采样以检测SsIgA。前瞻性地确定晚发性败血症（LOS）和坏死性小肠结肠炎（NEC）的发生率。组内和组间比较采用配对和独立样本检验。

结果

两组间基线特征相似。在DOL 7时，OAC组的SsIgA高于对照组（<0.05），但在随后的DOL 14时并非如此。LOS或NEC方面无差异。

结论

OAC在DOL 7时增加了SsIgA。需要进行一项大型多中心试验来确定OAC是否能降低VLBW婴儿的LOS或NEC。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5f/5685905/58b808440b5d/nihms887480f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5f/5685905/6772fbbb6f05/nihms887480f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5f/5685905/58b808440b5d/nihms887480f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5f/5685905/6772fbbb6f05/nihms887480f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc5f/5685905/58b808440b5d/nihms887480f2.jpg

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