Badiyan Shahed N, Molitoris Jason K, Chuong Michael D, Regine William F, Kaiser Adeel
Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, MD, USA.
Surg Oncol Clin N Am. 2017 Jul;26(3):431-453. doi: 10.1016/j.soc.2017.01.012. Epub 2017 May 11.
Pancreatic cancer is the third leading cause of cancer-related death in the United States. Although surgery remains the only curative treatment, chemotherapy and radiation therapy are frequently used. In the adjuvant setting, radiation is usually delivered with chemotherapy to eradicate residual microscopic or macroscopic disease in the resection bed. Neoadjuvant radiation therapy has become more frequently utilized. This article reviews the historical and modern literature regarding radiation therapy in the neoadjuvant and adjuvant settings, focusing on the evolution of radiation therapy techniques and clinical trials in an attempt to identify patients best suited to receiving radiation therapy.
胰腺癌是美国癌症相关死亡的第三大主要原因。尽管手术仍然是唯一的治愈性治疗方法，但化疗和放疗也经常被使用。在辅助治疗中，放疗通常与化疗联合使用，以根除切除床上残留的微小或肉眼可见的病灶。新辅助放疗的应用越来越频繁。本文回顾了关于新辅助和辅助治疗中放疗的历史和现代文献，重点关注放疗技术的演变和临床试验，试图确定最适合接受放疗的患者。
