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发作后呼吸暂停作为癫痫性猝死的重要机制:一例伴有连续脑电图-心电图-肌电图记录的接近癫痫性猝死病例

Postictal apnea as an important mechanism for SUDEP: A near-SUDEP with continuous EEG-ECG-EMG recording.

作者信息

Jin Lang, Zhang Ying, Wang Xiao-Li, Zhang Wen-Juan, Liu Yong-Hong, Jiang Zhao

机构信息

Department of Neurology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Department of Neurology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

出版信息

J Clin Neurosci. 2017 Sep;43:130-132. doi: 10.1016/j.jocn.2017.04.035. Epub 2017 May 30.

DOI:10.1016/j.jocn.2017.04.035
PMID:28576433
Abstract

Sudden unexpected death in epilepsy (SUDEP) is one of the most frequent causes of death among patients with epilepsy. Most SUDEP or near-SUDEP are unwitnessed and not observed or recorded during video-EEG recording in epilepsy monitoring units. This report describes a young woman with post ictal apnea and generalized EEG suppression (PGES) after a secondary generalized tonic-clonic seizure (sGTCS). This was accompanied by bradycardia and then ventricular tachycardia (VT). But at the end of VT, the patient's breath recovered without any intervention, such as cardio-respiratory resuscitation. This case report with continuous EEG, EKG, EMG during near SUDEP may provide insights into the mechanism of action.

摘要

癫痫猝死(SUDEP)是癫痫患者中最常见的死亡原因之一。大多数SUDEP或接近SUDEP的情况在癫痫监测单元进行视频脑电图记录期间未被目睹、观察或记录到。本报告描述了一名年轻女性,在继发性全面强直阵挛发作(sGTCS)后出现发作后呼吸暂停和广泛性脑电图抑制(PGES)。同时伴有心动过缓,随后出现室性心动过速(VT)。但在室性心动过速结束时,患者呼吸自行恢复,未进行任何诸如心肺复苏等干预措施。这份在接近SUDEP期间进行连续脑电图、心电图、肌电图监测的病例报告可能有助于深入了解其作用机制。

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1
Postictal apnea as an important mechanism for SUDEP: A near-SUDEP with continuous EEG-ECG-EMG recording.发作后呼吸暂停作为癫痫性猝死的重要机制:一例伴有连续脑电图-心电图-肌电图记录的接近癫痫性猝死病例
J Clin Neurosci. 2017 Sep;43:130-132. doi: 10.1016/j.jocn.2017.04.035. Epub 2017 May 30.
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Age-specific periictal electroclinical features of generalized tonic-clonic seizures and potential risk of sudden unexpected death in epilepsy (SUDEP).癫痫全面强直-阵挛发作的年龄特异性发作期电临床特征和癫痫猝死(SUDEP)的潜在风险。
Epilepsy Behav. 2013 Nov;29(2):289-94. doi: 10.1016/j.yebeh.2013.08.010. Epub 2013 Sep 5.
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Characteristics of postictal generalized EEG suppression in children.儿童癫痫发作后全脑电抑制的特征。
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Tonic electromyographic activity following bilateral tonic-clonic seizures is associated with periictal respiratory dysfunction and postictal generalized EEG suppression.双侧强直-阵挛性发作后出现紧张性肌电活动与发作期呼吸功能障碍和发作后广泛 EEG 抑制有关。
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Postictal generalized EEG suppression and respiratory dysfunction following generalized tonic-clonic seizures in sleep and wakefulness.睡眠和觉醒时全面性强直-阵挛发作后癫痫发作后全面性 EEG 抑制和呼吸功能障碍。
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Postictal immobility and generalized EEG suppression are associated with the severity of respiratory dysfunction.发作后不动和脑电图广泛性抑制与呼吸功能障碍的严重程度相关。
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Postictal generalized electroencephalographic suppression is associated with generalized seizures.发作后广泛的脑电图抑制与全身性发作有关。
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Equivocal significance of post-ictal generalized EEG suppression as a marker of SUDEP risk.发作后广泛性脑电图抑制作为SUDEP风险标志物的意义不明确。
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Causes and Effects Contributing to Sudden Death in Epilepsy and the Rationale for Prevention and Intervention.癫痫猝死的成因、影响及预防与干预的理论依据
Front Neurol. 2020 Jul 31;11:765. doi: 10.3389/fneur.2020.00765. eCollection 2020.
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The incidence and significance of periictal apnea in epileptic seizures.癫痫发作中发作期呼吸暂停的发生率及意义。
Epilepsia. 2018 Mar;59(3):573-582. doi: 10.1111/epi.14006. Epub 2018 Jan 16.