神经连接蛋白的翻译后修饰调节神经元和胶质细胞信号传导。
Posttranslational modifications of neuroligins regulate neuronal and glial signaling.
作者信息
Jeong Jaehoon, Paskus Jeremiah D, Roche Katherine W
机构信息
Receptor Biology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD 20892, USA.
Receptor Biology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD 20892, USA; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA.
出版信息
Curr Opin Neurobiol. 2017 Aug;45:130-138. doi: 10.1016/j.conb.2017.05.017. Epub 2017 May 31.
Abstract
This review covers the dynamic regulation of neuroligin isoforms, focusing on posttranslational events including phosphorylation, glycosylation and activity-dependent cleavage. There is a growing literature on how phosphorylation confers an isoform-specific level of modulation affecting a variety of protein interactions. In addition, recent studies describe activity-dependent proteolytic cleavage of neuroligins, revealing a broader role for neuroligins than just synaptic 'glue'. Interesting new research implicates the cleaved extracellular fragments of neuroligins in promoting glioma. These reports on cell signaling mediated by the cleavage products of neuroligins suggest novel and important roles for neuroligins in neuro-glial signaling.
摘要
本综述涵盖了神经连接蛋白亚型的动态调节，重点关注翻译后事件，包括磷酸化、糖基化和活性依赖性切割。关于磷酸化如何赋予影响多种蛋白质相互作用的亚型特异性调节水平的文献越来越多。此外，最近的研究描述了神经连接蛋白的活性依赖性蛋白水解切割，揭示了神经连接蛋白比仅仅作为突触“胶水”更广泛的作用。有趣的新研究表明，神经连接蛋白的细胞外裂解片段与促进胶质瘤有关。这些关于神经连接蛋白裂解产物介导的细胞信号传导的报告表明，神经连接蛋白在神经胶质信号传导中具有新的重要作用。
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本文引用的文献
1
Distinct roles for extracellular and intracellular domains in neuroligin function at inhibitory synapses.细胞外和细胞内结构域在抑制性突触神经连接蛋白功能中的不同作用。
Elife. 2016 Nov 2;5:e19236. doi: 10.7554/eLife.19236.
2
Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization.神经连接蛋白1通过LIMK1/丝切蛋白介导的肌动蛋白重组来调节棘突和突触可塑性。
J Cell Biol. 2016 Feb 15;212(4):449-63. doi: 10.1083/jcb.201509023.
3
Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin.星形胶质细胞通过Hevin桥接NRX1α和NL1来组装丘脑皮质突触。
Cell. 2016 Jan 14;164(1-2):183-196. doi: 10.1016/j.cell.2015.11.034.
4
The cellular and molecular landscape of neuroligins.神经连接蛋白的细胞和分子格局
Trends Neurosci. 2015 Aug;38(8):496-505. doi: 10.1016/j.tins.2015.06.004. Epub 2015 Jul 21.
5
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Glia. 2015 Nov;63(11):2023-2039. doi: 10.1002/glia.22875. Epub 2015 Jun 29.
6
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7
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8
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Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2551-6. doi: 10.1073/pnas.1500501112. Epub 2015 Feb 9.
9
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Nat Commun. 2014 Oct 9;5:5066. doi: 10.1038/ncomms6066.
10
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J Neurosci. 2014 Sep 3;34(36):11929-47. doi: 10.1523/JNEUROSCI.1860-14.2014.
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