Jeong Jaehoon, Paskus Jeremiah D, Roche Katherine W
Receptor Biology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD 20892, USA.
Receptor Biology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD 20892, USA; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA.
Curr Opin Neurobiol. 2017 Aug;45:130-138. doi: 10.1016/j.conb.2017.05.017. Epub 2017 May 31.
This review covers the dynamic regulation of neuroligin isoforms, focusing on posttranslational events including phosphorylation, glycosylation and activity-dependent cleavage. There is a growing literature on how phosphorylation confers an isoform-specific level of modulation affecting a variety of protein interactions. In addition, recent studies describe activity-dependent proteolytic cleavage of neuroligins, revealing a broader role for neuroligins than just synaptic 'glue'. Interesting new research implicates the cleaved extracellular fragments of neuroligins in promoting glioma. These reports on cell signaling mediated by the cleavage products of neuroligins suggest novel and important roles for neuroligins in neuro-glial signaling.
本综述涵盖了神经连接蛋白亚型的动态调节，重点关注翻译后事件，包括磷酸化、糖基化和活性依赖性切割。关于磷酸化如何赋予影响多种蛋白质相互作用的亚型特异性调节水平的文献越来越多。此外，最近的研究描述了神经连接蛋白的活性依赖性蛋白水解切割，揭示了神经连接蛋白比仅仅作为突触“胶水”更广泛的作用。有趣的新研究表明，神经连接蛋白的细胞外裂解片段与促进胶质瘤有关。这些关于神经连接蛋白裂解产物介导的细胞信号传导的报告表明，神经连接蛋白在神经胶质信号传导中具有新的重要作用。
