觉醒-睡眠神经回路：概述
Wake-sleep circuitry: an overview.
作者信息
Saper Clifford B, Fuller Patrick M
机构信息
Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States.
Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States.
出版信息
Curr Opin Neurobiol. 2017 Jun;44:186-192. doi: 10.1016/j.conb.2017.03.021. Epub 2017 May 31.
Abstract
Although earlier models of brain circuitry controlling wake-sleep focused on monaminergic and cholinergic arousal systems, recent evidence indicates that these play mainly a modulatory role, and that the backbone of the wake-sleep regulatory system depends upon fast neurotransmitters, such as glutmate and GABA. We review here recent advances in understanding the role these systems play in controlling sleep and wakefulness.
摘要
尽管早期控制觉醒-睡眠的脑回路模型聚焦于单胺能和胆碱能觉醒系统，但最近的证据表明，这些系统主要起调节作用，且觉醒-睡眠调节系统的主干依赖于快速神经递质，如谷氨酸和γ-氨基丁酸。我们在此综述了在理解这些系统在控制睡眠和觉醒中所起作用方面的最新进展。
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