Chao John, Pao Andrew
Peachtree Orthopaedic Clinic, 5505 Peachtree Dunwoody Road, Suite 600, Atlanta, GA 30342, USA.
Atlanta Medical Center, 303 Parkway Drive, Northeast, Atlanta, GA 30312-1212, USA.
Orthop Clin North Am. 2017 Jul;48(3):371-383. doi: 10.1016/j.ocl.2017.03.008.
Symptomatic osteochondral lesions of the talus remain a challenging problem due to inability for cartilage lesions to heal. Numerous treatment options exist, including nonoperative management, marrow stimulating techniques, and autograft-allograft. Arthroscopic marrow stimulation forms fibrocartilage that has been shown to be biomechanically weaker than hyaline cartilage. Restorative tissue transplantation options are being used more for larger and cystic lesions. Newer biologics and particulated juvenile cartilage are currently under investigation for possible clinical efficacy. This article provides an evidenced-based summary of available literature on the use of biologics for treatment of osteochondral lesions of the talus.
距骨有症状的骨软骨损伤仍然是一个具有挑战性的问题，因为软骨损伤无法愈合。存在多种治疗选择，包括非手术治疗、骨髓刺激技术和自体移植-异体移植。关节镜下骨髓刺激形成的纤维软骨在生物力学上已被证明比透明软骨更脆弱。修复性组织移植选项更多地用于较大的囊性病变。新型生物制剂和颗粒状青少年软骨目前正在研究其可能的临床疗效。本文提供了关于使用生物制剂治疗距骨骨软骨损伤的现有文献的循证总结。
