Abuabara Katrina, Margolis David J, Langan Sinéad M
Department of Dermatology, University of California San Francisco (UCSF), 2340 Sutter Street, N421, San Francisco, CA 94115, USA.
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel St, Bloomsbury, London WC1E 7HT, UK.
Dermatol Clin. 2017 Jul;35(3):291-297. doi: 10.1016/j.det.2017.02.003. Epub 2017 Apr 22.
Atopic dermatitis (AD) is a chronic, relapsing condition, meaning that the intensity of symptoms usually fluctuates over time. Changes in skin physiology may be evident from birth, suggesting that AD may be a lifelong condition marked by intermittent symptoms/disease activity. Methodological considerations for studying the long-term course of AD are reviewed in detail. Improved measurement of the frequency and duration of active disease periods can help to elucidate more about the clinical course AD and the role of treatment in long-term outcomes.
特应性皮炎（AD）是一种慢性复发性疾病，这意味着症状的严重程度通常会随时间波动。皮肤生理变化可能从出生时就很明显，这表明AD可能是一种以间歇性症状/疾病活动为特征的终身疾病。本文详细综述了研究AD长期病程的方法学考量。改进对疾病活动期频率和持续时间的测量，有助于更深入地了解AD的临床病程以及治疗在长期预后中的作用。
