Institut für Immunologie, Christian-Albrechts-Universität Kiel, Michaelisstr. 5, 24105 Kiel, Germany.
Institut für Immunologie, Christian-Albrechts-Universität Kiel, Michaelisstr. 5, 24105 Kiel, Germany.
Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2147-2161. doi: 10.1016/j.bbamcr.2017.05.025. Epub 2017 May 31.
Proteases control most of the physiological processes that occur in a cell. This particularly applies to apoptosis, the most well-studied form of cell death, where proteolysis by cysteine-aspartic proteases (caspases) is the primary mechanism for both initiation and execution of cell suicide. In contrast, the impact of proteolysis on other, non-apoptotic cell death pathways (summarized under the term "regulated necrosis", RN) has long been enigmatic, but has clearly been confirmed by a number of recent groundbreaking discoveries. Here, we review these discoveries and provide an overview on the role of proteolysis in known forms of RN, with a particular focus on necroptosis and pyroptosis, and their regulation by deubiquitinases, apoptotic and inflammatory caspases. This article is part of a Special Issue entitled: Proteolysis as a Regulatory Event in Pathophysiology edited by Stefan Rose-John.
蛋白酶控制着细胞中发生的大多数生理过程。这尤其适用于细胞凋亡，这是研究最充分的细胞死亡形式，其中半胱氨酸天冬氨酸蛋白酶（caspases）的蛋白水解是细胞自杀的起始和执行的主要机制。相比之下，蛋白水解对其他非凋亡细胞死亡途径（概括为“调节性坏死”，RN）的影响长期以来一直是个谜，但最近的一些突破性发现显然已经证实了这一点。在这里，我们回顾这些发现，并提供一个关于蛋白水解在已知形式的 RN 中的作用的概述，特别关注坏死性凋亡和细胞焦亡，以及它们被去泛素化酶、凋亡和炎症半胱天冬酶调节。这篇文章是由 Stefan Rose-John 编辑的特刊“蛋白水解作为病理生理学中的调节事件”的一部分。
