Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.
Int J Mol Med. 2018 Feb;41(2):624-630. doi: 10.3892/ijmm.2017.3279. Epub 2017 Nov 22.
Cell death is indispensable in the physiology, pathology, growth, development, senility and death of an organism. In recent years, the identification of a highly regulated form of necrosis, known as necroptosis, has challenged the traditional concept of necrosis and apoptosis, which are two major modes of cell death. This novel manner of cell death is similar in form to necrosis in terms of morphological features, and it can also be regulated in a caspase‑independent manner. Therefore, necroptosis can be understood initially as a combination of necrosis and apoptosis. The mechanism of its regulation, induction and inhibition is complicated, and involves a range of molecular expression and regulation. According to the recent literature, necroptosis takes place in the physiological regulatory processes of an organism and is involved in the occurrence, development and prognosis of a variety of diseases that have a necrosis phenotype, including neurodegenerative diseases, ischemic disease, hemorrhagic disease, inflammation and viral infectious diseases. In the present review, the features, molecular mechanism and identification of necroptosis under pathological conditions are discussed, with particular emphasis on its association with stroke.
细胞死亡在生物的生理、病理、生长、发育、衰老和死亡中是必不可少的。近年来，一种高度调控的坏死形式，即坏死性凋亡的鉴定，挑战了传统的细胞死亡的坏死和凋亡两种主要形式的概念。这种新的细胞死亡方式在形态学特征上与坏死相似，也可以不依赖于胱天蛋白酶的方式进行调节。因此，坏死性凋亡最初可以被理解为坏死和凋亡的结合。其调控、诱导和抑制的机制复杂，涉及一系列分子表达和调控。根据最近的文献，坏死性凋亡发生在生物体的生理调节过程中，并参与多种具有坏死表型的疾病的发生、发展和预后，包括神经退行性疾病、缺血性疾病、出血性疾病、炎症和病毒性传染病。在本综述中，讨论了病理条件下坏死性凋亡的特征、分子机制和鉴定，特别强调了其与中风的关系。
