Department of Physics and Astronomy "G. Galilei", University of Padua, 35131 Padua, Italy; Venetian Institute of Molecular Medicine (VIMM), Foundation for Advanced Biomedical Research, 35129 Padua, Italy; Department of Biomedical Sciences, Institute of Cell Biology and Neurobiology, Italian National Research Council, 00015 Monterotondo, (RM), Italy.
Department of Physics and Astronomy "G. Galilei", University of Padua, 35131 Padua, Italy; Venetian Institute of Molecular Medicine (VIMM), Foundation for Advanced Biomedical Research, 35129 Padua, Italy; Department of Biomedical Sciences, Institute of Protein Biochemistry, Italian National Research Council, 80131 Naples (NA), Italy.
Cell Calcium. 2018 Mar;70:117-126. doi: 10.1016/j.ceca.2017.05.006. Epub 2017 May 11.
In mammals, the sense of hearing arises through a complex sequence of morphogenetic events that drive the sculpting of the auditory sensory epithelium into its terminally functional three-dimensional shape. While the majority of the underlying mechanisms remain unknown, it has become increasingly clear that Ca signaling is at center stage and plays numerous fundamental roles both in the sensory hair cells and in the matrix of non-sensory, epithelial and supporting cells, which embed them and are tightly interconnected by a dense network of gap junctions formed by connexin 26 (Cx26) and connexin 30 (Cx30) protein subunits. In this review, we discuss the intricate interplay between Ca signaling, connexin expression and function, apoptosis and autophagy in the crucial steps that lead to hearing acquisition.
在哺乳动物中，听觉的产生是通过一系列复杂的形态发生事件驱动的，这些事件将听觉感觉上皮细胞塑造成其最终的三维功能形状。虽然大多数潜在的机制仍然未知，但越来越明显的是，钙信号处于中心地位，在感觉毛细胞和非感觉上皮和支持细胞基质中发挥着许多基本作用，这些细胞嵌入其中，并通过由连接蛋白 26（Cx26）和连接蛋白 30（Cx30）亚基形成的密集缝隙连接网络紧密相互连接。在这篇综述中，我们讨论了钙信号、连接蛋白表达和功能、细胞凋亡和自噬在导致听力获得的关键步骤中的复杂相互作用。
