Erskine K J, Iversen S A, Davies R
Lancet. 1985 Mar 9;1(8428):554-5. doi: 10.1016/s0140-6736(85)91210-3.
As a part of a larger study, 15 healthy primigravidas were studied from 28 weeks gestation until 3 days after deliver. In 6 of these women pre-eclampsia (PET) developed; the remaining 9 subjects, who were age matched had normal pregnancies. Plasma phospholipid-esterified 18:2(9,11):18:2(9,12)fatty acids were measured by high performance liquid chromatography (HPLC). The ratio of 18:2(9,11):18:2(9,12)linoleic acid was significantly higher in the PET group than in the normotensive group at 28 weeks' gestation--that is before the onset of symptoms and signs of PET. The ratio remained significantly higher in the PET group than in the normotensive group until deliver, except at 30 weeks when the difference between the ratios just failed to reach statistical significance. It is suggested that measurement of the ratio of 18:2(9,11) to 18:2(9,12)linoleic acid in plasma phospholipids may be useful as a predictor of the likely development of PET.
作为一项更大规模研究的一部分，对15名健康初产妇从妊娠28周直至产后3天进行了研究。其中6名女性发生了先兆子痫（PET）；其余9名年龄匹配的受试者妊娠情况正常。采用高效液相色谱法（HPLC）测定血浆磷脂酯化的18:2(9,11):18:2(9,12)脂肪酸。在妊娠28周时，即PET症状和体征出现之前，PET组中18:2(9,11):18:2(9,12)亚油酸的比例显著高于血压正常组。直到分娩时，PET组中的该比例仍显著高于血压正常组，但在30周时，两组比例之间的差异刚刚未达到统计学显著性。提示测定血浆磷脂中18:2(9,11)与18:2(9,12)亚油酸的比例可能有助于预测PET的可能发生情况。
