Jendryczko A, Drozdz M
Department of Biochemistry and Chemistry, Silesian Medical School, Katowice.
Zentralbl Gynakol. 1989;111(16):1121-3.
20 healthy primigravidas were studied from 28 weeks' gestation until 4 days after delivery. In 9 of these women pre-eclampsia developed, the remaining 11 subjects who were age-matched had normal pregnancies. Plasma retinol, beta-carotene and vitamin E concentrations were measured by high performance liquid chromatography. The concentrations of retinol and vitamin E were significantly lower in the pre-eclampsia group than in the normotensive group at 28 weeks' gestation--that is before the onset of symptoms and signs of pre-eclampsia. The concentrations of retinol and vitamin E remained significantly lower in the pre-eclampsia group until delivery. It is suggested that measurement of the retinol or vitamin E concentration in plasma may be useful as a predictor of the likely development of pre-eclampsia.
对20名健康初产妇进行了研究，从妊娠28周直至产后4天。其中9名妇女发生了先兆子痫，其余11名年龄匹配的受试者妊娠正常。采用高效液相色谱法测定血浆视黄醇、β-胡萝卜素和维生素E浓度。在妊娠28周时，即先兆子痫症状和体征出现之前，先兆子痫组的视黄醇和维生素E浓度显著低于血压正常组。先兆子痫组的视黄醇和维生素E浓度在分娩前一直显著较低。提示测定血浆视黄醇或维生素E浓度可能有助于预测先兆子痫的发生。
