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冬凌草甲素通过阻断Notch信号通路抑制乳腺癌的生长和转移。

Oridonin inhibits breast cancer growth and metastasis through blocking the Notch signaling.

作者信息

Xia Shixin, Zhang Xiulan, Li Caihong, Guan Honglian

机构信息

Pharmaceutical Preparation Section, Weifang People's Hospital, Weifang 261500, China.

Intravenous Drug Dispensing Section, Weifang People's Hospital, Weifang 261500, China.

出版信息

Saudi Pharm J. 2017 May;25(4):638-643. doi: 10.1016/j.jsps.2017.04.037. Epub 2017 May 10.

DOI:10.1016/j.jsps.2017.04.037
PMID:28579904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5447451/
Abstract

BACKGROUND

Oridonin is a diterpenoid isolated from with potent anticancer activity. The aim of our study is to investigate the role of oridonin to inhibit growth and metastasis of human breast cancer cells.

METHODS

The effect of oridonin on proliferation was evaluated by MTT assay, cell migration and invasion were evaluated by transwell migration and invasion assays in human breast cancer cells. The inhibitive effect of oridonin was determined by using xenografted nude mice. In addition, the expression of Notch receptors (Notch 1-4) was detected by western blot.

RESULTS

Oridonin inhibited human breast cancer cells and . In addition, oridonin significantly induced human breast cancer cells apoptosis. Furthermore, the oridonin treatment not only inhibited cancer cell migration and invasion, but more significantly, decreased the expression of Notch 1-4 protein.

CONCLUSION

Our results suggest that the inhibitive effect of oridonin is likely to be driven by the inhibition of Notch signaling pathway and the resulting increased apoptosis.

摘要

背景

冬凌草甲素是从[具体来源未提及]中分离出的一种具有强大抗癌活性的二萜类化合物。我们研究的目的是探讨冬凌草甲素在抑制人乳腺癌细胞生长和转移中的作用。

方法

采用MTT法评估冬凌草甲素对人乳腺癌细胞增殖的影响，通过Transwell迁移和侵袭实验评估细胞迁移和侵袭能力。利用异种移植裸鼠确定冬凌草甲素的抑制作用。此外，通过蛋白质免疫印迹法检测Notch受体（Notch 1-4）的表达。

结果

冬凌草甲素抑制人乳腺癌细胞[具体细胞名称未提及]和[具体细胞名称未提及]。此外，冬凌草甲素显著诱导人乳腺癌细胞凋亡。此外，冬凌草甲素处理不仅抑制癌细胞迁移和侵袭，更显著的是，降低了Notch 1-4蛋白的表达。

结论

我们的结果表明，冬凌草甲素的抑制作用可能是通过抑制Notch信号通路以及由此导致的细胞凋亡增加来实现的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00a9/5447451/72a69670a530/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00a9/5447451/92ba6a28965b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00a9/5447451/62ad80d931c4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00a9/5447451/49a588438d0d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00a9/5447451/35c861cd8177/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00a9/5447451/72a69670a530/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00a9/5447451/92ba6a28965b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00a9/5447451/62ad80d931c4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00a9/5447451/49a588438d0d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00a9/5447451/35c861cd8177/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00a9/5447451/72a69670a530/gr5.jpg

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2
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3
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4
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Molecules. 2024 Jun 4;29(11):2643. doi: 10.3390/molecules29112643.
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